Proteins and Peptides Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes Drugs and the Pharmaceutical Sciences Series
Coordonnateurs : Mrsny Randall J., Daugherty Ann
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Hematologic Growth Factors and Cytokines. In Vitro–In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Antibody Therapeutics. In Vitro/In Vivo Correlations of Pharmacokinetics, Pharmacodynamics, and Metabolism for Extracellular Matrix–Binding Growth Factors. Metabolic Processes at Injection Sites Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Protein and Peptide Therapeutics. Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Proteins and Peptides. Engineering as a Means to Improve the Pharmacokinetics of Injected Therapeutic Proteins. Ophthalmic Delivery of Protein and Peptide Therapeutics; Pharmacokinetics, Pharmacodynamics, and Metabolism Considerations. Pharmacokinetic and Pharmacodynamic Aspects of Intranasal Delivery. Oral Delivery of Protein and Peptide Therapeutics: PK/PD and Metabolism Considerations. Drug Interaction Studies of Therapeutic Biologics: Protein and Peptide Actions and Interactions That Alter Their Pharmacokinetics, Pharmacodynamics, and Metabolism. Intersection of Pharmacogenomics with Pharmacokinetics and Pharmacodynamics.
Date de parution : 10-2019
15.2x22.9 cm
Date de parution : 10-2009
Ouvrage de 400 p.
15.2x22.9 cm
Thème de Proteins and Peptides :
Mots-clés :
FcRn Binding; White Cell; therapeutic; Anti-drug Antibody Responses; vascular; Antidrug Antibody Responses; endothelial; DMPK Gene; growth; FBGC Formation; factor; Nasal Surface Area; therapeutics; FGF-2 Bind; drug; Stem Cell; delivery; SC Injection Site; dosage; Peg Chain; form; High Dose IFN A2b; Human FcRn; HS Chain; SC Space; Free Growth Factor; CYP450 System; Activate KRAS Mutation; Antidrug Antibody; Permeation Enhancers; Peptide Therapeutic; Focal Chronic Inflammation; Peptide Drugs; Hematopoietic Cytokines; Free IgE