Protein Ligation and Total Synthesis II, 2015 Topics in Current Chemistry Series, Vol. 363

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Hydroxyamine ketoacid ligation.- Chemical synthesis of proteins using N-sulfanylethylanilide peptides based on N-S acyl transfer chemistry.- Post ligation Desulfurization: A General Approach for Chemical Protein Synthesis.- Solid phase chemical synthesis of proteins.- New methods for protein chemical synthesis.- the chemical preparation of modified histones.