Protein Kinase Inhibitors in Research and Medicine
Auteur : Shokat Kevan M
Zhihong Wang and Philip A. Cole.
2. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs
Qi Wang, Julie A. Zorn and John Kuriyan.
3. Fragment-Based Approaches to the Discovery of Kinase Inhibitors
Paul N. Mortenson, Valerio Berdini and Marc O’Reilly.
4. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors
Rand M. Miller and Jack Taunton.
5. The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-resistant Protein Kinase Alleles
Veselin I Andreev and Patrick A Eyers
6. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations
Jeffrey R. Simar and Daniel Rauh
7. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate
Nathanael S. Gray and Doriano Fabbro
8. The Logic and Design of Analog-Sensitive (AS) Kinases and their Small Molecule Inhibitors
Michael S. Lopez, Joseph Kliegman and Kevan M. Shokat
Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists
- Continues the legacy of this premier serial with quality chapters authored by leaders in the field
- Covers research methods in biomineralization science
- Contains sections focusing on protein kinase inhibitors in research and medicine
Date de parution : 11-2014
Ouvrage de 252 p.
15x22.8 cm
Thème de Protein Kinase Inhibitors in Research and Medicine :
Mots-clés :
Allosteric inhibitor; ATP; BCR-ABL; Bisubstrate analog; B-Raf; Cancer; Chemical rescue; Crystal structure; Drug; EGFR; Erlotinib; Fragment libraries; Fragment screening; Fragment-based drug design; Fragments; Gatekeeper; Hinge; Inhibitor; Kinase; Kinase inhibitor; Kinase inhibitors; Kinome; Lapatinib; Ligand; Mutation; Myristate-pocket binders; Polypharmacology; Resistance; Src; Structure-based drug design; T315I gatekeeper mutation; Transition state