Protein Delivery, 2002 Physical Systems Pharmaceutical Biotechnology Series, Vol. 10

Protein delivery from biodegradable microspheres. Degradable controlled release systems useful for protein delivery. Delivery of proteins from a controlled release injectable implant. Protein delivery from non-degradable polymer matrices. Diffusion controlled delivery of proteins from hydrogels and other hydrophilic systems. Poly(ethylene glycol)-coated nanospheres : potential carriers for intravenous drug administration. Multiple emulsion protein delivery systems. Transdermal peptide delivery using electroporation. Protein delivery with infusion pumps. Oral delivery of microencapsulated proteins. Controlled delivery of somatotropins. Insulin iontophoresis. Insulin formulation and delivery.

Protein Delivery from Biodegradable Microspheres.- Degradable Controlled Release Systems Useful for Protein Delivery.- Delivery of Proteins from a Controlled Release Injectable Implant.- Protein Delivery from Nondegradable Polymer Matrices.- Diffusion-Controlled Delivery of Proteins from Hydrogels and Other Hydrophilic Systems.- Poly(ethyleneglycol)-Coated Nanospheres: Potential Carriers for Intravenous Drug Administration.- Multiple Emulsions for the Delivery of Proteins.- Transdermal Peptide Delivery Using Electroporation.- Protein Delivery with Infusion Pumps.- Oral Delivery of Microencapsulated Proteins.- Controlled Delivery of Somatotropins.- Insulin Iontophoresis.- Insulin Formulation and Delivery.

Thirteen chapters present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. Highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.