Progress in Medicinal Chemistry

1. Property-Based Design in the Optimisation of Benzamide Glucokinase Activators: From Hit to Clinic

Darren McKerrecher and Michael J. Waring

2. Medicinal Chemistry of Glucagon-like Peptide Receptor Agonists

Lyn H. Jones and David A. Price

3. Antimalarial Drug Discovery: Recent Progress and Future Directions

Felix Calderón, David M. Wilson and Francisco-Javier Gamo

4. Advances in the Discovery of Selective JAK Inhibitors Christel J. Menet, Luc Van Rompaey and Raphael Geney

Chemists, biologists, doctors, pharmacists and anyone interested in the contemporary controversy about drugs, drug firms, and the community

From 2003 to 2007 he was founding Research Director with Lectus Therapeutics building from start-up a drug discovery organisation; generating the team, facilities and project portfolio targeting the next generation of ion channel modulating medicines.

Since 2001 Geoff has provided scientific and strategic evaluation and advice on drug discovery as an independent consultant for a number small and medium sized biotech companies, CROs, VCs, academic groups and medical research charities.

Geoff serves on the Board of Antabio, a French biotech company developing tomorrow’s antibacterial drugs.

He is a founder of INMedD, a new medicines discovery social enterprise.
Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.

In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. Davi

• Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry
• This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems