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Phage Display In Biotechnology and Drug Discovery (2nd Ed.) Drug Discovery Series

Langue : Anglais

Coordonnateurs : Sidhu Sachdev S., Geyer Clarence Ronald

Couverture de l’ouvrage Phage Display In Biotechnology and Drug Discovery

Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies.

The book provides readers with an overview of the amazing breadth of the impact that phage display technology has had on the study of proteins in general as well as the development of proteins. It will be a valuable resource for those interested in using phage display and recombinant antibodies in basic research and drug discovery.

Key Features:

  • Describes the basic principles of phage display and the methods and systems that have been developed for key applications
  • Outlines applications for peptide phage display in the development of vaccines and high- throughput screens as well as the exploration of protein?protein interactions and enzyme substrate characteristics
  • Details the use of phage display in the engineering of protein stability, the identification and mapping of protein?protein interactions, and the development of catalysts
  • Provides broad coverage of the impact of phage display technology on the development of protein therapeutics
  • Presents expert opinions on future challenges in the field

Filamentous Bacteriophage Structure and Biology. Vectors and Modes of Display. Methods for the Construction of Phage-Displayed Libraries. Selection and Screening Strategies. Leveraging Synthetic Phage-Antibody Libraries for Panning on the Mammalian Cell Surface. Phage Libraries for Developing Antibody-Targeted Diagnostics and Vaccines. Exploring Protein-Protein Interactions Using Peptide Libraries Displayed on Phage. Substrate Phage Display. Mapping Intracellular Protein Networks. High-Throughput and High-Content Screening Using Peptides. Engineering Protein Folding and Stability. Identification of Natural Protein-Protein Interactions with cDNA Libraries. Mapping Protein Functional Epitopes. Selections for Enzymatic Catalysts. Antibody Humanization and Affinity Maturation Using Phage Display. Antibody Libraries from Immunized Repertoires. Naive Antibody Libraries from Natural Repertoires. Synthetic Antibody Libraries. Engineering Antibody Fragments for Intracellular Applications.

Graduate, postdoctoral and senior researchers in the fields of therapeutic biotechnology and protein engineering and researchers interested in recombinant antibodies.

Edited by

Sachdev S. Sidhu, PhD, professor, Department of Molecular Genetics, University of Toronto, Ontario, Canada

C. Ronald Geyer, PhD, professor, Department of Pathology, University of Saskatchewan, Canada