PET and SPECT of Neurobiological Systems (2^nd Ed., 2nd ed. 2021)

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ?-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

PART I BASICS: Animal Models for Brain Research.- Small Animal Molecular Imaging - μPET, μSPECT.- Cerebral Glucose Metabolism.- Cerebral Blood Flow Measurement with 15O-Water PET.- Principles of Brain Perfusion SPECT.- The Impact of Genetic Polymorphisms on Neuroreceptor Imaging.- PART II SYSTEMS:  Acetylcholinesterase.- Adenosine Receptors.- Beta-Amyloid and Other Proteinopathies.- Central Benzodiazepine Receptors.- Cyclooxygenase-2.- Dopamine System in Humans.- Endocannabinoid System.- Glutamate Receptors (Metabotropic).- Histamine H3 Receptors.- Hormone Receptors (Steroids).- Monoamine Oxidase B.- MRP1 Function in the BBB.- Neuroinflammation: From Target Selection to Preclinical and Clinical Studies.- Nicotinic Acetylcholine Receptors.- NMDA Receptors.- Norepinephrine Transporter.- Opioid Receptors.- P-Glycoprotein and Other ABC Transporters.- Phosphodiesterases.- Purinergic Receptors.- Serotonin System.- Serotonin Transporter and Monoamine Oxidase A.- Sigma-1 Receptors.- Sigma-2 Receptors.- Synaptic Density (SV2A).- Tau Pathology.- Translocator Protein.- Tropomyosin Receptor Kinase.- Vesicular Acetylcholine Transporter.- Vesicular Monoamine Transporter.

Rudi Dierckx studied medicine and neuropsychiatry at the Free University of Brussels. He was trained as a nuclear medicine physician at the University of Antwerp (1988-1994). Rudi has headed the Department of Nuclear Medicine at the University Hospital of Ghent (Belgium) from 1994 to 2004, and has acquired a Master of Business Administration (MBA) at the Vlerick School of Management in Leuven (2004, cum laude). Since 2005 he is Head of the Department of Nuclear Medicine and Molecular Imaging at University Medical Center Groningen (UMCG) in The Netherlands.  Since 2013, he is also Head of the Medical Imaging Center, and Chairman ad interim of the Department of Radiology at UMCG. His primary research interests are PET studies of the human brain.

Andreas Otte, MD, is a board-certified specialist in Nuclear Medicine and Professor of Biomedical Engineering in the Division of Medical Engineering, Department of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Germany. Prof. Otte received his graduate and post-graduate medical education at the University Hospitals Freiburg, Germany, and Basle, Switzerland, and at the Paul Scherrer Research Institute in Villigen, Switzerland. Thereafter he held various leading positions in clinical research with Pfizer in Freiburg, Germany (International Medical Research, Pfizer Global Pharmaceuticals) and at the University Hospital Freiburg. From 2002 to 2009 he was Visiting Professor of Nuclear Medicine in the Medical Faculty of the University of Ghent in Belgium. He took up his present position in 2010. Andreas Otte is the author of many peer-reviewed journal articles and the author or editor/co-editor of a number of books. His research focus is on neurosciences including functional neuroimaging, brain-machine-interfaces, and intelligent neuroprosthetics. Awarded a series of international scientific prizes, he was nominated Editor of the Board of the European Journal ofN