Pancreatic Cancer

This handbook details advances in pancreatic cancer research that have a profound and lasting impact on the field. It features the work of authors who are the very best in their respective fields and will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.

Section One: The Nature of Pancreatic Cancer

1. Epidemiology: world overview, risk factors, prospects for prevention
2. Development and structure of pancreas
3. Pathologic classification and biological behaviour of pancreatic neoplasia
4. Developmental molecular biology of the pancreas
5. Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)
6. Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer
7. Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis
8. Sporadic neuroendocrine pancreatic tumours
9. Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer
10. Miscellaneous non-pancreatic non-endocrine tumours
11. Novel molecular relationships between chronic pancreatitis and cancer
12. Pancreatic cancer stem cells
13. Cell cycle control: signalling pathways in pancreatic pathogenesis
14. Apoptosis: signalling pathways in pancreatic pathogenesis
15. EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK
16. Hedgehog: signalling pathways in pancreatic pathogenesis
17. Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis
18. Notch signalling in pancreatic morphogenesis and pancreatic cancer
19. Molecular characterization of pancreatic cell lines
20. Mouse models of exocrine pancreatic cancer
21. Principles and applications of microarray gene expression in pancreatic cancer
22. Principles and applications of proteomics in pancreatic cancer
23. Tumour-stromal interaction: invasion and metastases
24. Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes
25. Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1

Section Two: Clinical Management of Pancreatic Cancer

26. Clinical decision making in pancreatic cancer
27. Paraneoplastic syndromes
28. Diagnostic and therapeutic response markers
29. CT and fusion PET-CT Diagnosis, staging, and follow-up
30. MRI and MRCP: diagnosis and staging of pancreatic cancer
31. EUS Diagnosis and staging
32. Laparoscopy and laparoscopic ultrasound: diagnosis and staging
33. Overview of palliative management for pancreatic cancer
34. Endoscopy.
35. Interventional radiology
36. Role of palliative surgery in advanced pancreatic cancer
37. Chemotherapy for advanced pancreatic cancer
38. Developments in chemoradiation in advanced pancreatic cancer
39. Surgical resection for pancreatic cancer
40. Role of venous resection in pancreatic cancer surgery
41. Pathological reporting and staging following resection
42. Japanese Pancreas Society staging for pancreatic cancer
43. Adjuvant chemotherapy in pancreatic cancer
44. Case for adjuvant chemoradiation therapy for pancreatic cancer
45. Case for neoadjuvant treatment in pancreatic cancer
46. Borderline resectable disease
47. Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms
48. Laparoscopic surgery for pancreatic neoplasm
49. Modern Japanese approach to pancreas cancer

Section Three: New Directions

50. Development of novel biomarkers
51. Inherited genetics of pancreatic cancer and secondary screening
52. Gene therapy for pancreatic cancer
53. Vaccine therapy and immunotherapy
54. Emerging targets in pancreatic cancer

The only Major Reference Work devoted entirely to pancreatic cancer

The contributing authors to this book are the very best in their respective fields

Will have widespread appeal among clinicians, pathologists, and basic scientists who are now struggling to understand this complex and rapidly growing field