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Osteogenesis Imperfecta A Translational Approach to Brittle Bone Disease

Langue : Anglais

Coordonnateurs : Kassim Javaid, Sponseller Paul

Rédacteur en Chef : Shapiro Jay R.

Couverture de l’ouvrage Osteogenesis Imperfecta

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.



  • Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta (OI) as will the importance of nutrition in managing the OI child and the OI adult
  • Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI
  • Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future
  • Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI

Foreword

Acknowledgments

List of Contributors

Section 1: INTRODUCTION

Section 2: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY

Section 3: CLINICAL AND MOLECULAR GENETICS OF OSTEOGENESIS IMPERFECTA

Section 4: COL1A1 AND COL1A2 MUTATIONS

Section 5: ANIMAL MODELS OF OSTEOGENESIS IMPERFECTA

Section 6: BRITTLE BONE OVERLAP PHENOTYPES: TGF-BETA MUTATIONS AND BONE

Section 7: CLINICAL ASPECTS OF OSTEOGENESIS IMPERFECTA

Section 8: ORGAN INVOLVEMENT IN OSTEOGENESIS IMPERFECTA

Chapter 9: ORTHOPEDICS

Section 10: PHYSICAL MEDICINE AND REHABILITATION

Section 11: PHARMACOLOGIC TREATMENT OF OSTEOGENESIS IMPERFECTA

Section 12: GENETIC APPROACH TO TREATMENT OF OSTEOGENESIS IMPERFECTA

Index

Biomedical researchers and research clinicians in the fields of endocrinology, orthopedics, pediatrics, rheumatology, and genetics, who study and treat bone diseases

Dr. Jay R. Shapiro is a graduate of Franklin and Marshall College and the Boston University School of Medicine. He serves as Professor in the Department of Physical Medicine and Rehabilitation and Director of the Bone and Osteogenesis Imperfecta Department at the Kennedy Krieger Institute. He served as Director of the General Clinical Research Center at Johns Hopkins University and is on the Medical Advisory Committee of the Osteogenesis Imperfecta Foundation. Dr. Shapiro also served as the Chief for the Bone Team of the National Space Biomedical Research Institute.

Dr. Shapiro has specialty interests in endocrine, metabolic and genetic disorders of bone. Current research activities include: heart disease in adult osteogenesis imperfecta, the effect of nutrition on bone growth in osteogenesis imperfecta, osteoporosis in Rett syndrome and a study of the effects of bisphosphonate treatment during microgravity on the International Space Station (NASA).

Date de parution :

Ouvrage de 578 p.

21.6x27.6 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

215,20 €

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