Organophosphorus Reagents A Practical Approach in Chemistry The Practical Approach in Chemistry Series

Organophosphorus Chemistry: A Practical Approach in Chemistry provides a practical introduction to the field by mixing a brief review of the subject area with key experimental details and sample procedures. Phosphorus is an element that has been central to the development of our modern way of life. Its chemistry plays a key role in the development of such important areas as pharmaceuticals, agrochemicals, modern materials and molecular biology. Much of this work requires a sound understanding of the organic chemistry of phosphorus and this volume is designed to instruct the reader in the essential methodology used. Topics covered include phosphines, applications of phosphorus (III) and (V) compounds as reagents in synthesis, the chemistry of phosphorus ylides, applications of the Wittig reaction in the synthesis of heterocyclic and carbocyclic compounds, preparation of Iminophosphoranes and their synthetic applications in the aza-Wittig reaction, phospho-transfer processes leading to [P-C] bond formation, low valent phosphorus compounds and phosphorus methods in oligonucleotide chemistry. It is intended not only for the specialist in organophosphorus chemistry, but also for the organic chemist with little experience in the field who wishes to add phophorus-based techniques to his or her ensemble of synthetic methods.

1: Dr P.J. Murphy: Introduction to "Organophosphorus Chemistry", 2: Professor Jonathan Williams and Matthew Clarke: The synthesis and applications of Phosphines, 3: Dr R. Alan Aitken and Nazira Karodia: Applications of phosphorus (III) and (V) compounds as reagents in synthesis, 4: Dr Andrew Abell and Dr Michael Edmonds: The Wittig and related Reactions, 5: Dr Ranier Schobert: Applications of the Wittig reaction in the synthesis of heterocyclic and carbocyclic compounds, 6: Dr. Part 1: O.Neil and Dr J.M. Southern: Preparation and reactions of Iminophosphoranes and their synthetic applications in the aza-Wittig reaction, 7: Dr Matthew D. Fletcher: Phospho-Transfer processes leading to (P-C) bond formation, 8: Dr Sven Asmus, Dr Uwe Bergstrasser, Dr Heinrich Heydt, Dr Marion Schmitz and Professor Manfred Regitz: Low-coordinated phosphorus compounds, 9: Dr David M. Williams and Dr Vicki H. Harris: Phosphorus methods in nucleotide chemistry

Dr Patrick J Murphy is currently a senior lecturer in Organic Chemistry at the University of Wales, Bangor. His research interests include organo-phosphorus chemistry, guanidine chemistry and natural product synthesis