Optical coherence tomography: technology & applications (Biological & medical physics, biomedical engineering)

Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. A new generation OCT technology has now been developed, representing a quantum leap in resolution and speed, achieving in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in real time. Functional extensions of OCT technology enable non-invasive, depth resolved functional assessment and imaging of tissue. These new techniques should not only improve image contrast, but should also enable the differentiation of pathologies via metabolic properties or functional state. The book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading international research groups, in a style comprehensible to a broad audience. It will be of interest not only to physicists, scientists and engineers, but also to biomedical and clinical researchers from different medical specialties.

Introduction to Optical Coherence Tomography.- Theory of Optical Coherence Tomography.- Modeling Light-Tissue Interaction in Optical Coherence Tomography Systems.- Part I Optical Coherence Tomography Technology.- Dual Beam Interferometers and Novel Optical Coherence Tomography.- Spectral/Fourier Domain Optical Coherence Tomography.- Complex and Coherence-Noise Free Fourier Domain Optical Coherence Tomography.- Optical Frequency Domain Imaging.- Ultrahigh Resolution Optical Coherence Tomography.- Superluminescent Diode Light Sources for OCT.- Broad Bandwidth Laser and Nonlinear Optical Light Sources for OCT.- Wavelength Swept Lasers.- Optical design for OCT.- Data Analysis and Signal Post-Processing for Optical Coherence Tomography.- Part II En Face Optical Coherence Tomography and Optical Coherence Microscopy.- Linear OCT.- En-face Flying Spot OCT/Ophthalmoscope.- Acousto Optic Modulator Based En Face OCT.- Optical Coherence Microscopy.- Combined MPM/OCT System and Second Harmonic OCT.- Full-Field Optical Coherence Tomography.- Holographic Optical Coherence Imaging.- Part III Optical Coherence Tomography Extensions.- Doppler Optical Coherence Tomography.- Polarization-Sensitive Optical Coherence Tomography.- Using Low Coherent Light for Spectroscopic Information from Tissue.- Molecular OCT Contrast Enhancement and Imaging.- Ultrasensitive Phase-Resolved Imaging of Cellular Morphology and Dynamics.- Combined Endoscopic Optical Coherence Tomography and Laser Induced Fluorescence.- Elastic Scattering Spectroscopy and Optical Coherence Tomography.- Optical Tissue Clearing to Enhance Imaging Performance for OCT.- Optical Coherence Tomography in Tissue Engineering.- Part IV Optical Coherence Tomography Applications.- OCT Applications in Developmental Biology.- Anterior Eye Imaging with Optical Coherence Tomography.- Retinal Optical Coherence Tomography.- Optical Coherence Tomography for Gastrointestinal Endoscopy.- Imaging Coronary Atherosclerosis and Vulnerable Plaques with Optical Coherence Tomography.- OCT in Dermatology.- OCT in Laryngology.- Dental OCT.- Optical Coherence Tomography in Pulmonary Medicine.- OCT in Gynecology.- Optical Coherence Tomography in Urology.- Anatomical Optical Coherence Tomography of the Human Upper Airway.- Development of OCT Technology for Clinical Applications

From the reviews:"This is a comprehensive review of the current status of optical coherence tomography (OCT) technology and its applications in the medical field. ... The authors are the leading experts in this field and as such are able to use a unique approach for targeting physicists, scientists, engineers, and researchers in medical specialties, along with practitioners. The book is also suitable for graduate students and residents interested in pursuing an education in medical specialties." (Paul Gueye, Doody's Review Service, June, 2009)