Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors Progress in Molecular Biology and Translational Science Series
Auteur : KENAKIN Terry
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.
Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.
- Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
- Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
- Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
- G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
- GPCRs in Stem Cell Function
- Application of Receptor Theory to Allosteric Modulation of Receptors
- What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
- Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
- Chemokine Receptor Oligomerization and Allostery
- Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac
Michael T. Klein, Paige N. Vinson and Colleen M. Niswender
Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender
Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis
Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri
Van A. Doze and Dianne M. Perez
David A. Hall
Frederick J. Ehlert
Jesús Giraldo
Bryan Stephens and Tracy M. Handel
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Date de parution : 04-2013
Ouvrage de 488 p.
15x22.8 cm
Mots-clés :
Allosteric modulator; Metabotropic glutamate receptor; Schizophrenia; Fragile X syndrome; Parkinson's disease; Anxiety; Mutagenesis; Allosteric site; G protein-coupled receptor; Cancer; Oligomerization; Signal transduction; Tyrosine kinase receptor; Angiogenesis; Pharmacology; Drug design; GPCR; Stem cell; Embryonic; Mesenchymal; Pluripotent; Cancer; Cardiac; Neural; Induced pluripotent; Constitutive activity; Cubic ternary complex model; Intrinsic efficacy; Operational model; Protean agonism; Receptor inactivation; Two-state model; GABAA receptor; Allosterism; Cys-loop receptor; G protein-coupled receptors; Probe dependence; Allosteric agonist; Agonist bias; Monod Wyman#x2013Changeux; Two-state model; M2 muscarinic receptor; GPCR; Receptor oligomerization; Dimer receptors; Cooperativity; Allosterism; Mathematical modeling; G protein-coupled receptor; Chemokine receptor; Oligomerization; Dimerization; Allostery; CCR2; CCR5; CXCR2; CXCR4; CXCR7; DARC; GPCR signaling; G protein activation; RGS protein; GPSM protein; Nonreceptor GEF; Protein#x2013protein interaction
