Nutrients in Cancer Prevention and Treatment, 1995 Experimental Biology and Medicine Series, Vol. 27

Nutrients in Cancer Prevention and Treatment contains articles that were presented by leading researchers and physicians in the field of nutritional oncology. Most of the previous conference proceedings on Nutrition and Cancer have dealt primarily with the issue of the role of nutrients in cancer prevention. This is logical because enormous quantities of laboratory and epi­ demiologic data have been published on the topic. Nutrients in Cancer Prevention and Treatment also contains several studies on the role of diet and vitamins in cancer treat­ ment. There are very few books that have reviewed laboratory and clinical studies and the role of vitamins in cancer treatment. There are preliminary data suggesting that daily supplementa­ tion with high doses of certain vitamins in combination with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells, and may protect normal tissues against some of their toxic effects. This book is unique in the sense that several articles have discussed the mechanisms of action of individual vitamins on cellular and molecular parameters. It is very exciting to note that some of the vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes. These studies, at least in part, offer rationales for the cancer protective effects of vitamins.

Part I. Carcinogenesis. G Protein Pathways and Regulation of Neoplastic Transformation. Part II. Cancer Prevention Studies: Lab Studies. Vitamin E Succinate Inhibits Protein Kinase C: Correlation with Its Unique Inhibitory Effects on Cell Growth and Transformation. Vitamin E Succinate: Mechanisms of Action as Tumor Cell Growth Inhibitor. Vitamin D, Gene Expression, and Cancer. Mechanisms of Cancer Prevention: Effects of Protease Inhibitors on Proteases and Gene Expression. Antioxidants and Cancer Prevention In Vivo and In Vitro. Ascorbic Acid and Gastrointestinal Cancer. Biochemistry and Pharmacology of Retinoids in Relation to Chemoprevention of Cancer. Involvement of Retinoic Acid Nuclear Receptors in Transcriptional Regulation of Tissue Transglutaminase, the Gene Involved in Apoptosis. Mechanisms of Dietary Fat-Induced Colon Cancer Promotion. Calories and Exercise as Modifiers of Cancer Risk. Polcyclic Aromatic Hydrocarbon-DNA Adducts in Smokers and Their Relationship to Micronutrient Levels and Glutathione-S-Transferase M1 Genotype. Aspects of Commercial Deep-Fat Frying of Fallafel and Its Relation to Liver Tumor. Part III. Cancer Prevention Studies: Human Studies. Antioxidant Vitamins and Cancer: The Physicians' Health Study and Women's Health Study. Beta-Carotene and Antioxidant Nutrients in Oral Cancer Prevention. Nutritional Prevention Trials for Colorectal Neoplasia. Part IV. Cancer Treatment Studies: Lab Studies. Vitamins Induce Cell Differentiation, Growth Inhibition, and Enhance the Effect of Tumor Therapeutic Agents on Some Cancer Cells In Vitro. Molecular and Biochemical Control of Tumor Growth Following Treatment with Carotenoids or Tocopherols. Inhibition and Regression of Experimental Oral Cancer by Beta Carotene and Vitamin E: Emerging Concepts. Novel Approaches to the Prevention of Chemotherapy-Induced Alopecia. Part V. Cancer Treatment Studies: Human Studies. Role of Vitamin A and Its Derivatives in the Treatment of Human Cancer. Use of Vitaminsas Adjunct to Conventional Cancer Therapy. Orthomolecular Treatment of Cancer. Index.