Neuropathic Pain Causes, Management and Understanding

Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.

Preface; Part I. The Clinical Presentation of Neuropathic Pain: 1. History and physical examination Pam Squire and John Xavier Pereira; 2. Diagnostic testing in chronic neuropathic pain patients Vishal Gupta and Michael Serpell; 3. Epidemiological considerations in neuropathic pain Didier Bouhassira and Nadine Attal; Part II. The Condition of Neuropathic Pain: 4. An overview of animal models for neuropathic pain Patrick L. Stemkowski and Peter A. Smith; 5. Peripheral and central sensitization Cory Toth; 6. Pathophysiology of neuropathic pain: voltage-gated sodium and calcium channels Robyn Flynn and Christophe Altier; 7. Pathophysiology of neuropathic pain: inflammatory mediators Paul J. Austin and Gila Moalem-Taylor; 8. Pathophysiology of neuropathic pain: signaling pathways and their magnification – the role of neuronal toll-like receptors Michael R. Due, Yohance M. Allete and Fletcher A. White; Part III. The Specific Condition: Peripheral Neuropathic Pain: 9. Diabetic and other peripheral neuropathies Cory Toth; 10. Postherpetic neuralgia: the prevention of a scourge C. Peter N. Watson; 11. Painful conditions affecting the nerve roots and plexus Kristine M. Chapman and Amanda Sherwin; Part IV. The Specific Condition: Central Neuropathic Pain: 12. Neuropathic pain following spinal cord injury Jan H. Vranken; 13. Central pain symptoms in multiple sclerosis Scott Jarvis and Bradley J. Kerr; 14. Central post-stroke pain Maan Kattan and Dwight E. Moulin; Part V. The Specific Condition: Other Causes of Neuropathic Pain: 15. The complex regional pain syndromes and post-traumatic neuralgias Anne Louise Oaklander and Steven H. Horowitz; 16. The management of neuropathic pain in cancer patients Wojciech Leppert; 17. Fibromyalgia Mary-Ann Fitzcharles and Peter Ste-Marie; Part VI. The Management of Neuropathic Pain: 18. Antidepressants: TCA and SNRIs Maija Haanpää; 19. Gabapentinoids and other anticonvulsants Howard S. Smith, Charles E. Argoff, Manpreet Kaur and Harsha Nagaraja; 20. Opioids Andrea D. Furlan and Angela Mailis-Gagnon; 21. Cannabinoids Mark A. Ware; 22. Local anesthetics and other interventional approaches Ian Carroll; 23. Spinal cord stimulation and other neuromodulation Krishna Kumar and Syed Rizvi; 24. Drug synergy and therapeutic combinations Stephan A. Schug; 25. The person with pain perspective and participation – an essential component of successfully managing chronic neuropathic pain Lynn Kerene Cooper; Part VII. The Prognosis of Neuropathic Pain: 26. Measuring outcomes in chronic neuropathic pain Nadine Attal; 27. Impact of chronic pain upon anxiety, sleep, and mood dimensions Scott Jarvis and Cory Toth; 28. Impact upon related conditions and quality of life Bharati Vyawahare and John Hughes; 29. The future: new concepts and potential therapies Nicole M. Sumracki, Lauren Nicotra, Yuen Kwok, Liang Liu, Krista van Steeg, Linda R. Watkins and Mark R. Hutchinson; Index.

Cory Toth MD is an Associate Professor in the Department of Clinical Neurosciences, a member of the Hotchkiss Brain Institute and Research Director at the Calgary Chronic Pain Clinic, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada.
Dwight E. Moulin MD is a Professor in the Departments of Clinical Neurological Sciences and Oncology and is the Earl Russell Chair of Pain Medicine, University of Western Ontario, London, Ontario, Canada.