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Mucosal Delivery of Biopharmaceuticals, Softcover reprint of the original 1st ed. 2014 Biology, Challenges and Strategies

Langue : Anglais

Coordonnateurs : das Neves José, Sarmento Bruno

Couverture de l’ouvrage Mucosal Delivery of Biopharmaceuticals
Biopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of  molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e.g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration.   Following a brief introduction ,the first section addresses general aspects of the biology of mucosal tissues and their unique aspects towards beneficial or deleterious interaction with biopharmaceuticals and their delivery systems. The second part reviews the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications of drug delivery systems/products enclosing biopharmaceuticals for mucosal delivery, with a focus on the most successful case studies of recent years. The last section briefly centers on relevant aspects of the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals.​   Scientists and researchers in the fields of drug delivery, material science, biomedical science and bioengineering, as well as professionals, regulators and policy makers in the pharmaceutical, biotechnology and healthcare industries will find in this book an important compendium of fundamental concepts and practical tools for their daily research and activities.
Section I. Biology of Mucosal Sites 1.      Function and Structural Organization of Mucosal Tissues-Jeffrey P. Pearson 2.      Disease and Pathology at Mucosal Sites-Jerrold R. Turner 3.      Concepts on Mucosal Immunity-Jiri Mestecky 4.      Mucoadhesion: Basic Principles and Applications-Nicholas A. Peppas 5.      Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems-Justin Hanes 6.      Mucosal Permeation and Absorption Mechanisms of Biopharmaceuticals-Hsing-Wen Sung   Section II. Delivery Strategies for Specific Mucosal Sites 7.      Oral Delivery of Biopharmaceuticals-Bruno Sarmento 8.      Buccal Delivery of Biopharmaceuticals-Sevda Şenel 9.      Pulmonary Delivery of Biopharmaceuticals-Ben Forbes 10.    Nasal Delivery of Biopharmaceuticals-Kenji Kono 11.    Ocular Delivery of Biopharmaceuticals-Arto Urtti 12.    Vaginal Delivery of Biopharmaceuticals-José das Neves   Section III. Case Studies of Mucosal Delivery of Biopharmaceuticals 13.    Nanoparticles-in-Microsphere Oral System (NiMOS) for Gene Delivery and Silencing-Mansoor Amiji 14.    Glucan-Based Particles as Oral Delivery Vehicles for siRNA-Michael P. Czech 15.    Bacteria-Based Vectors for Oral Gene Therapy-Fenyong Liu 16.    Cholesteryl-Group-Bearing Pullulan Nanogels for Nasal Delivery of Biopharmaceuticals-Hiroshi Kiyono 17.    Delivery Strategies for Developing siRNA-Based Vaginal Microbicides-Nigel A. J. McMillan 18.    Cell-Penetrating Peptides for Mucosal Delivery of Peptides and Proteins-Mariko Morishita 19.    Antigen Delivery Strategies for Large-Scale Veterinary Mucosal Immunization-Juan Manuel Irache 20.    Eligen® Technology for Oral Delivery of Proteins and Peptides-M. Cristina Castelli 21.    The RapidMist™ System for Buccal Delivery of Insulin-Kim Henriksen 22.    Formulation and Pulmonary Delivery Aspects of Dornase Alpha (Pulmozyme®)-Paolo Pozzilli 23.    Development of the Exubera® Insulin Pulmonary Delivery System-Nancy J. Harper 24.    The Technosphere® Inhalation System for Pulmonary Delivery of Biopharmaceuticals-James P. Cassidy 25.    ChiSys® as a Chitosan-Based Delivery Platform for Nasal Vaccination-Peter J. Watts 26.    Development and Performance of the Cyclosporine A Ophthalmic Emulsion (Restasis®)-Michael E. Stern 27.    Development of a Cationic Nanoemulsion Platform (Novasorb®) for Ocular Delivery-Jean-Sebastien Garrigue   Section IV. Regulatory, Toxicological and Market Issues 28.    Regulatory Aspects and Approval of Biopharmaceuticals for Mucosal Delivery-Keith Wonnacott 29.    Delivery of Biopharmaceuticals by Mucosal Routes: Toxicological Considerations-Paul Baldrick 30.    Market Impact of Biopharmaceutical Products for Mucosal Delivery-Gary Walsh

José das Neves is a researcher at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, and in the Faculty of Pharmacy, University of Porto, Portugal, where he earned a Ph.D. in Pharmaceutical Sciences. His previous work has spanned multiple aspects of the development of vaginal drug delivery systems, and his current research interests include the development of nanotechnology-based solutions for the development of anti-HIV microbicides and mucosal delivery of biopharmaceuticals.

Bruno Sarmento is an affiliated researcher at INEB – Instituto de Engenharia Biomédica, University of Porto, Portugal. He is also an assistant professor of pharmaceutical and biopharmaceutical technology at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal. He earned a Ph.D. in Pharmaceutical Technology at the University of Porto. He has extensive work in the development of nanocarriers for the oral delivery of biopharmaceuticals—namely insulin—and the establishment of novel in vitro intestinal permeability models. His current research focuses on nanomedicines and their applications in the pharmaceutical and biomedical fields.

First book exclusively dedicated to the mucosal delivery of biopharmaceutical drugs Feature 15 case studies of drug product development​

Explores the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals

Examines new technological strategies and challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration

Date de parution :

Ouvrage de 601 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 177,46 €

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Date de parution :

Ouvrage de 601 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 210,99 €

Ajouter au panier
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