Monoclonal antibodies : production, engineering and clinical application (Postgraduate medical science, 3) paper Postgraduate Medical Science Series

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.

1. Introduction, 2. Production of monoclonal antibodies, 3. Antigen–antibody interactions: how affinity and kinetics affect assay design and selection procedures, 4. The production and characterisation of synthetic peptide-derived antibodies, 5. Human monoclonal antibodies, 6. Bispecific monoclonal antibodies, 7. The production of antibodies using phage display libraries, 8. Genetic manipulation of monoclonal antibodies, 9. Monoclonal antibodies in diagnostic immunoassays, 10A. Monoclonal antibodies in diagnostic pathology, 10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies, 11A. Monoclonal antibodies in infectious disease: diagnosis, 11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease, 12A. Monoclonal antibodies in transplantation: immunohistology, 12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression, 12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation, 12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation, 13. Monoclonal antibodies and the skin, 14. Monoclonal antibodies in endocrinology, 15. Monoclonal antibodies in rheumatology, 16. Technical appendix.