Molecular Imaging of Small Animals, 2014 Instrumentation and Applications

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development.

In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.

Scintillation detectors for small-animal imaging.- Solid-state detectors for small-animal imaging.- Photodetectors for small-animal imaging instrumentation.- Design considerations of small-animal SPECT cameras.- Design considerations of small-animal PET scanners.- Design considerations of small-animal CT systems.- Small-animal MRI instrumentation.- Preclinical optical molecular imaging.- Advances in radiotracer development for molecular imaging.- Image registration for multimodality small-animal imaging.- Dual-modality preclinical SPECT/PET instrumentation.- Dual-modality preclinical SPECT/CT instrumentation.- Dual-modality preclinical PET/CT instrumentation.- Dual-modality preclinical SPECT/MR instrumentation.- Dual-modality preclinical PET/MR instrumentation.- Dual-modality preclinical PET/OI instrumentation.- Quantification of small-animal multimodality imaging data.- Animal handling and preparation for imaging.- Applications ofmolecular small-animal imaging in neurology and psychiatry.- Applications of molecular small-animal imaging in cardiology.- Applications ofmolecular small-animal imaging in oncology.- Applications ofmolecular small-animal imaging in inflammation and infection.- Role ofsmall-animal molecular imaging of gene expression.- Applications ofmolecular small-animal imaging in drug development.- Multimodality molecular imaging: A futuristic outlook.

Habib Zaidi, Ph.D is Chief Physicist and head of the PET Instrumentation & Neuroimaging Laboratory at Geneva University Hospital and faculty member at the medical school of Geneva University. He is also a Professor of Medical Physics at the University Medical Center of Groningen (The Netherlands) and visiting Professor at Ecole Nationale Supérieure d’Electronique et de ses Applications (ENSEA, France). Dr. Zaidi is actively involved in developing imaging solutions for cutting-edge interdisciplinary biomedical research and clinical diagnosis in addition to lecturing undergraduate and postgraduate courses on medical physics and medical imaging.

Explores the rapidly expanding field of multimodality small-animal molecular imaging

Examines various imaging modalities including CT, MRI, SPECT and PET

Demonstrates the increasing role of in vivo small-animal imaging in understanding human molecular biology and pathophysiology

Includes supplementary material: sn.pub/extras