Mitochondrial Signaling in Health and Disease Oxidative Stress and Disease Series

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:

• Electron transport and energy production
• Mitochondrial biogenesis and dynamics
• Mitochondrial signaling
• Apoptosis and autophagy
• Pharmacology signaling
• Epigenetic signaling: mitochondrial methylation and acetylation reactions

An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Mitochondria—Reactive Oxygen Species (ROS)—Cell Death. A Healthy Free Radical Pessimism: A Glance from an Oxidative Lipidomics Corner. Mitochondrial Involvement in the Execution of Cell Death. The Role of Protein Kinase C in Mitochondrial Functions in Cardiac Ischemia- Reperfusion Injury. Mitocans, Mitochondria-Targeting Anticancer Drugs: Focus on Mitochondrial Complexes. Therapeutic Potential of Lipoamide and Enhanced Mitochondrial Biogenesis for Treatment of Insulin Resistance. Mitochondria-Targeted Antioxidants.Mitochondria—Metabolism—Nitric Oxide. Lactate Shuttling and the Mitochondrial Lactate Oxidation Complex. Nitric Oxide in the Regulation of Mitochondrial Biogenesis. Effect of Sildenafil on Heart Nitric Oxide Metabolism and Mitochondrial Function. Kinases and Mitochondrial Cycling: The Last Encounter. Acetylation—Deacetylation—Aging. Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics: Implications in Age-Associated Diseases. Mitochondrial Protein Acetylation and Sirtuin-Mediated Deacetylation. Mitochondrial Regulation by Protein Acetylation. Calorie Restriction, Mitochondria, and Longevity in Sacchaomyces cerevisiae. Autophagy and Aging: Keeping Organelles and the Proteome Healthy. Neurodegeneration. Mitochondrial Dynamics and Its Implications in Metabolic Dysregulation and Neurodegeneration. Mitochondrial Abnormalities and Oxidative Stress in Alzheimer’s Disease: Can Mitochondrial Reactive Oxygen Species Signaling Promote Neuronal Survival? The Role of Mitochondria in Parkinson’s Disease and Huntington’s Disease.α-Ketoglutarate Dehydrogenase Complex in Neurodegeneration. R-α-Lipoic Acid as a Potent Agent of Mitochondrial Protection in Alzheimer’s Disease. Mitochondrial Antioxidants in Neuroprotection.

Sten Orrenius, M.D., Ph.D., holds honorary memberships in the American Society for Pharmacology and Experimental Therapeutics, the American Society for Biochemistry and Molecular Biology, the Society of Toxicology (USA), as well as the Italian and Swedish Societies of Toxicology. He is also a Member of the Royal Swedish Academy of Sciences and a Foreign Associate Member of the Institute of Medicine of the National Academy of Sciences, USA. Dr Orrenius has received honorary doctorates from the Universities of Stockholm, Turin, Konstanz, Buenos Aires, Paris V and Milan. He earned the Merit Award by EUROTOX, the Association of European Toxicologists and Societies of Toxicology, in 1997 and was the recipient of the 2006 Distinguished Lifetime Toxicology Scholar Award by the Society of Toxicology (USA). In 2003, Dr. Orrenius received the first ECDO Career Award for Excellence in Cell Death Research by the European Cell Death Organization.

Enrique Cadenas,