Mitochondria and Their Role in Cardiovascular Disease, 2013

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine.  The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Section I.- General principles of mitochondria and the heart 1.- Introduction to mitochondria in the heart 2.-Methods to study mitochondrial structure and function 3.- Mitochondrial structure, composition and dynamics 4.- Mitochondrial biogenesis 5.- Mechanisms of bioenergy production in mitochondria 6.- Bioenergetics interplay between cardiac mitochondria and other subcellular compartments Section II.- Heart mitochondria signal transduction: Stem cells 7) Endothelial mitochondria: Contribution to cardiovascular function and  disease 8.- Heart mitochondria: Receivers and transmitters of signals 9.- Stem cells and mitochondria Section III.- Stress and cell death 10.- Heart mitochondrial ROS and oxidative stress 11.- Cell death pathways and mitochondria Section IV.- Mitochondria in pediatric cardiology 12.- Mitochondria in pediatric cardiovascular diseases Section V.- The aging heart and mitochondria 13.- Mitochondrial in the aging heart Section VI.- Mitochondria in atherosclerosis, hypertension and ischemia 14.- The role of mitochondria in atherosclerosis 15.- The role of mitochondria  in hypertension 16.- Role of mitochondria in ischemia and cardioprotection Section VII.- Mitochondria in heart failure and dysrhythmias 17.- Mitochondrial dynamics in health and disease 18.- Mitochondria play an essential role in heart failure 19.- Mitochondria and cardiac dysrhythmias Section VIII.- Mitochondria in heart metabolism 20.- Diabetes and cardiac mitochondria 21.- The role of mitochondria in metabolic syndrome and insulin resistance 22.-Thyroid hormone and myocardial mitochondria Section IX.- Mitochondrial therapy 23.- Targeting the mitochondria in cardiovascular diseases Section X.- Looking to the future of mitochondria and the heart 24.- Current progress and future perspectives: Towards mitochondrial medicine

José Marín-García, MD

The Molecular Cardiology and Neuromuscular Institute

Highland Park, NJ, USA

Brings readers up-to-date on the many significant advances in the field of mitochondrial cardiovascular medicine

Presents cutting-edge information on the expanding role of mitochondria on major cardiovascular diseases

Emphasis on biological understanding and clinical impact

Includes supplementary material: sn.pub/extras