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MicroRNAs as Tools in Biopharmaceutical Production, 2012

Langue : Anglais

Coordonnateur : Barron Niall

Couverture de l’ouvrage MicroRNAs as Tools in Biopharmaceutical Production

Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells,  miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.

Preface 1 A general introduction to microRNAs, their investigation and exploitation in CHO cell lines 2 Biogenesis of Mammalian miRNA 3 Target prediction algorithms and bioinformatics resources for miRNA studies 4 The CHO miRNA transcriptome 5 MicroRNAs as engineering targets - pathway manipulation to impact bioprocess phenotypes 6 MicroRNAs for Enhancement of CHO Cell Proliferation and Stability Insights from Neuroblastoma Studies 7 MicroRNA Detection Methods for Mammalian Cell Lines and Their Applications in Therapeutic Protein Production 8 Manipulating Levels of Specific microRNAs in Mammalian Cells Index.

Biology of microRNAs for use as tools

Implementation of these molecules to improve processes in the Biopharmceutical field

Methods to implement these molecules in the Bioprocess setting

Includes supplementary material: sn.pub/extras

Includes supplementary material: sn.pub/extras

Date de parution :

Ouvrage de 126 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 105,49 €

Ajouter au panier

Date de parution :

Ouvrage de 126 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 105,49 €

Ajouter au panier

Thème de MicroRNAs as Tools in Biopharmaceutical Production :