Medicinal Chemistry of Anticancer Drugs (3^rd Ed.)

Langue : Anglais

Auteurs : Avendaño Carmen, Menéndez J. Carlos

Couverture de l’ouvrage Medicinal Chemistry of Anticancer Drugs

Résumé
Sommaire
Biographie
Commentaire

This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents.

Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature.

1. Introduction
2. Antimetabolites
3. Anticancer Drugs That Modulate Hormone Action
4. Anticancer strategies involving radical species
5. DNA Alkylating Agents
6. Anticancer Drugs That Interact with the DNA Minor Groove
7. Anticancer Drugs acting by DNA intercalation and topoisomerase inhibition
8. Epigenetic Therapy of Cancer
9. Anticancer Drugs Targeting Tubulin and Microtubules
10. Drugs Tacting on signaling pathways, part 1: Tirosine kinase inhibitors
11. Anticancer drugs acting on signaling pathways, part 2
12. Protein degradation-based cancer therapy
13. Cancer immunotherapy
14. Miscellaneous small-molecule and biological approaches to cancer therapy
15. Drug Targeting in Anticancer Chemotherapy
16. Drugs That Modulate Resistance to Anticancer Agents
17. Cancer Chemoprevention

Mª del Carmen Avendaño López received her doctoral degree in Pharmacy at the Complutense University of Madrid (UCM) in 1970. In 1986, she became Full Professor of Organic Chemistry at the Department of Organic and Pharmaceutical Chemistry of this university, being responsible for one of its research groups. Between 1993 and 2009, she was a member of the Scientific Advising Committee for the Profarma Program, organized by the Spanish Ministry for Industry to incentivize research activities at the pharmaceutical industry. She was appointed Vice-rector in charge of Postgraduate Degrees at the International University “Menéndez y Pelayo in 2005-2007. She participated in the development of the Spanish Society for Therapeutical Chemistry and has also been a member of several scientific international societies and assessment committees. Since 1999, she is a Fellow of the Spanish National Royal Academy of Pharmacy where she is in charge of all activities related to Medicinal Chemistry, with particular focus on the relevance of chemistry in drug discovery and development. She has co-authored several chapters in periodical series and encyclopedias, including “Comprehensive Heterocyclic Chemistry and “Science of Synthesis, and has edited and co-authored several Medicinal Chemistry textbooks, most notably “Introducción a la Química Farmacéutica, published by McGraw-Hill Interamericana in 1993 and 2001. In 2008, she co-authored with Dr. Menéndez the first edition of “Medicinal Chemistry of Anticancer Drugs“ for Elsevier. Her research activities, documented in about 200 publications and some patents in collaboration with the pharmaceutical industry, have dealt with the development of synthetic methodologies to obtain biologically active molecules, with particular focus on antitumor natural compounds.
José Carlos Menéndez was born in Madrid (1960) and obtained degrees in Pharmacy from Universidad Complutense at Madrid, UCM (1982, with Excellence Award) and Chemistry from U

Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view
Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures
Features a large number of color figures which give information in a clear-and-concise way
Includes extensive references to review articles and primary literature
Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer