Liver Disease in Children (5^th Ed.)

Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Section 1. Pathophysiology of Pediatric Liver Disease: 1. Liver development; 2. Functional development of the liver; 3. Mechanisms of bile formation and the pathogenesis of cholestasis; 4. Acute liver failure in children; 5. Cirrhosis and chronic liver failure in children; 6. Portal Hypertension in children; 7. Laboratory assessment of liver function and injury in children; Section 2. Cholestatic Liver Disease: 8. Approach to the infant with cholestasis; 9. Medical and nutritional management of cholestasis in infants and children; 10. Neonatal hepatitis and congenital infections; 11. Biliary atresia and other disorders of the extrahepatic bile ducts; 12. Neonatal jaundice and disorders of bilirubin metabolism; 13. Familial hepatocellular cholestasis; 14. Alagille Syndrome; 15. Intestinal failure associated liver disease; 16. Diseases of the gallbladder in infancy, childhood, and adolescence; Section 3. Hepatitis and Immune Disorders: 17. Hepatitis A and hepatitis E virus in children; 18. Hepatitis B virus infection in children; 19. Hepatitis C virus infection in children; 20. Autoimmune hepatitis in children; 21. Sclerosing cholangitis in children; 22. Drug-induced liver disease in children; 23. Liver disease in immunodeficiencies in children; Section 4. Metabolic Liver Disease: 24. Laboratory diagnosis of inborn errors of liver metabolism; 25. α1-Antitrypsin Deficiency; 26. Cystic fibrosis liver disease in children; 27. Inborn errors of carbohydrate metabolism; 28. Copper metabolism and copper storage disorders in children; 29. Iron storage disorders in children; 30. Heme biosynthesis and the porphyrias in children; 31. Tyrosinemia in children; 32. Lysosomal storage disorders in children; 33. Disorders of bile acid synthesis and metabolism in children; 34. Inborn errors of fatty acid oxidation; 35. Mitochondrial hepatopathies; 36. Non-alcoholic fatty liver disease in children; 37. Peroxisomal disorders in children; 38. Urea cycle disorders in children; Section 5. Other Considerations and Issues in Pediatric Hepatology: 39. Bacterial, parasitic, and fungal infections of the liver in children; 40. Systemic disease and the liver in children; 41. Fibrocystic liver disease in children; 42. Tumors of the liver in children; 43. Liver transplantation in children: indications and surgical aspects; 44. Liver transplantation in children: post-transplant care.

Frederick J. Suchy MD is Professor of Pediatrics, Chief Research Officer, Digestive Health Institute, Section of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, and University of Colorado School of Medicine, Aurora, CO, USA.
Ronald J. Sokol MD is Arnold Silverman MD Endowed Chair in Digestive Health, Chief, Section of Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, and University of Colorado School of Medicine, Aurora, CO, USA.
William F. Balistreri MD is Dorothy M. M. Kersten Professor of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, Cincinnati, OH, USA.