Lipids in Protein Misfolding, 1st ed. 2015 Advances in Experimental Medicine and Biology Series, Vol. 855

?Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence  protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

Explains how protein misfolding is an important biological phenomenon underlying over 20 major human diseases Shows that Lipids importantly influence protein misfolding and amyloid diseases Provides an up-to-date analysis of the roles of lipids in protein misfolding Discusses a wide array of proteins, lipids and their modes of interaction Focusses on the biophysical and structural properties of the interacting partners Complements the small collection of books on this topic in this rapidly developing field