Life-Threatening Effects of Antipsychotic Drugs
Coordonnateurs : Manu Peter, Flanagan Robert J., Ronaldson Kathlyn J.
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.
Part I: Cardiovascular Adverse Effects of Antipsychotic Drugs
Chapter 1 - Sudden Cardiac Death and Ventricular Arrhythmias
Peter Manu, Anca Dan and Gheorghe-Andrei Dan
Chapter 2 - Myocarditis and Cardiomyopathy
Kathlyn J. Ronaldson
Chapter 3 - Pulmonary Embolism
Peter Manu, Christopher Hohman, James F. Barrecchia, and Matisyahu Shulman
Chapter 4 - Orthostatic Hypotension
James J. Gugger and Megan J. Ehret
Part II: Hematological Complications of Treatment With Antipsychotic Drugs
Chapter 5 - Severe Neutropenia and Agranulocytosis
John Lally and Robert J. Flanagan
Part III: Antipsychotic-Related Pathology of the Digestive System
Chapter 6 - Gastrointestinal Hypomotility and Dysphagia
Robert J. Flanagan and Kathlyn J. Ronaldson
Chapter 7 - Liver Failure
Katie F.M. Marwick
8. Pancreatitis
Peter Manu, Matisyahu Shulman and Kathlyn J. Ronaldson
Part IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic Drugs
Chapter 9 - Seizures
Tilman Steinert and Walter Fröscher
Chapter 10 - Neuroleptic Malignant Syndrome
Julie Langan Martin and Daniel J. Martin
Chapter 11 - Heat Stroke and Rhabdomyolysis
Kathlyn J. Ronaldson
Part V: Metabolic Complications of Antipsychotic Drug Treatment
Chapter 12 - Type 2 Diabetes Mellitus
Davy Vancampfort, Richard I.G. Holt, Brendon Stubbs, Marc De Hert, Katherine Samaras and Alex J. Mitchell
Part VI: Other Life-Threatening Effects of Antipsychotic Drugs
Chapter 13 - Interstitial Nephritis and Interstitial Lung Disease
Kathlyn J. Ronaldson
Part VII: Clinical and Forensic Challenges in the Use of Antipsychotic Drugs
Chapter 14 - The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of Life
Jian-Ping Zhang
Chapter 15 - Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical Management
Dan Cohen
Chapter 16 - Forensic Investigation of Antipsychotic-Related Deaths
Robert J. Flanagan and Peter Manu
Professor Bob Flanagan is Consultant Clinical Scientist and Director, Toxicology Unit, King’s College Hospital NHS Foundation Trust and Clinical Lead for Toxicology, Sheffield Teaching Hospital NHS Foundation Trust. He has published over 200 scientific papers and four books. Particular interests have been treatment of mental illness especially as regards use of antipsychotics, notably clozapine, treatment of cancer, especially in respect of the use of tyrosine kinase inhibitors such as imatinib, and the diagnosis of substance abuse, especially misuse of volatiles such as butane. He led on toxicology training for the Association for Clinical Biochemistry for many years, and regularly advises medical professionals, police, coroners, and prosecution and defence lawyers on toxicological issues. He has also acted as a consultant to the United Nations Office for Drugs and Crime, most recently as regards advising on methodology for the detection of drug-facilitated crime, and to the World Health Organization, notably in Serbia/Kosovo in 2007, and also in the Middle East and in India. He is immediate past-President of the British Academy of Forensic Sciences.
- Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects
- Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness
- Discusses clozapine rechallenge after each of its serious adverse reactions
- Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy
- Includes data on post-mortem considerations
Date de parution : 08-2016
Ouvrage de 394 p.
15x22.8 cm
