Laron Syndrome - From Man to Mouse, 2011 Lessons from Clinical and Experimental Experience

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

From the Content: Part I - Laron Syndrome in Man.- Clinical Aspects.- History of the Israeli Cohort of Laron Syndrome Patients.- Early Investigations.- Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome.- Diagnosis of Laron Syndrome.- Genetic Aspects.- Clinical Evaluation.- Perinatal Evaluation.- Perinatal Development ;Laron Syndrome.- Linear Growth Pattern of Untreated Laron Syndrome Patients.- Head Shape, Size and Growth of Untreated Patients with Laron Syndrome.- Sexual Development in Patients with Laron Syndrome.

First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him) Describes the comprehensive pathophysiology of IGF-I deficiency and gives valuable advice for the IGF-I treatment Compares IGF-I and GH deficiency and illustrates the effects of the treatment, e.g. metabolic effects, adipose tissue alterations and the effects on aging Includes supplementary material: sn.pub/extras