Judah Folkman, 1st ed. 2018 A Biography
Auteur : Ribatti Domenico
The aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to tumor growth. Without new blood vessels, tumors simply did not thrive. In 1971, Folkman published his theory of angiogenesis in the ?New England Journal of Medicine?. Angiogenesis, the formation and recruitment of new blood vessels, is necessary for tumor growth. Critics of the theory were silenced over time as Folkman and his colleagues reported the first purified angiogenic molecule, the first angiogenesis inhibitor and proposed the concept of angiogenic disease. The mechanism of angiogenesis is now a worldwide field of investigation. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.
- Biographic profile
- Development of assays to study angiogenesis
2.1.The rabbit cornea
2.2.The chorioallantoic membrane
2.3 Culture of endothelial cells
3. Tumor angiogenesis3.1. Early evidence that tumor cells release specific growth factors for endothelial cells
3.2. Absence of angiogenesis in tumors in isolated perfused organs
3.3. Tumor growth is angiogenesis-dependent
3.4. The concept of angiogenic switch
3.5. The avascular and vascular phases of solid tumor growth
3.6. Angiogenesis and metastasis
3. 7. Prognostic significance of tumor vascularity
4. The discovery of angiogenic factors
4.1. Isolation of the first tumor angiogenesis factor
4.2. The discovery of FGF
4.3. The discovery of VPF/VEGF
5. Anti-angiogenesis
5.1. Inhibition of angiogenesis by a diffusible factor from cartilage
5.2. Endogenous, direct and indirect inhibitors
5.3. Inteferon alpha5.4. Platelet factor 4/Protamine
5.5. Angiostatic steroids
5.6. Fumagillin
5.7. Angiostain and endostatin
5.8. Thalidomide
5.9. 2-methoxyestradiol and cleaved antithrombin III
5.10. Anti-angiogenic chemotherapy
6. Concluding remarks
7. References
8. Publications of Judah Folkman (2014-1956)
Judah Folkman is recognized as the modern father of angiogenesis research worldwide
Folkman isolated the first tumor angiogenesis factor (TAF)
From 1980 to 2005, Folkman’s laboratory reported the discovery of 11 angiogenesis inhibitors
Angiogenesis and anti-angiogenesis are now two of the most important fields in modern biomedicine
Date de parution : 02-2019
Ouvrage de 124 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 105,49 €
Ajouter au panierDate de parution : 07-2018
Ouvrage de 124 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 105,49 €
Ajouter au panierMots-clés :
angiogenesis; anti-angiogenesis; history of medicine; tumor growth; vascular biology
