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Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications

Langue : Anglais

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Couverture de l’ouvrage Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin

Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity. Aromatic d lactones or isocoumarins with thiaisocoumarins, phosphaisocoumarins and a-pyranone fused with a heteroaryl ring constitute an important class of heterocyclic compounds. This book provides the methods applied for the synthesis of thiaisocoumarins, phosphaisocoumarins, and a-pyranone fused with a heteroaryl ring. It is useful to medicinal and natural product chemists who want to synthesize target molecules and develop cutting-edge technologies to provide better solutions to researchers.

1. Introduction: The diverse aromatic d lactones2. Natural products: A major source of isocoumarins3. Bioactive isocoumarins: their role in pharmaceutical research4. Synthesis of isocoumarins: traditional and transition metal catalyzed methods5. Preparation of Thienopyranones6. Synthesis of seleno and telluro isocoumarins7. Synthesis of a-pyranone fused with nitrogen containing heterocycles8. Synthesis of phosphaisocoumarins9. Synthesis of nature’s isocoumarins10. Synthesis of isocoumarins of pharmacological interest11. Isocoumarins in organic synthesis: Synthetic applications12. Conclusions

Researchers in academia and industry working in the area of oxygen containing heterocycles, transition metal catalysis, synthetic methodologies, medicinal / pharmaceutical / natural product chemistry and drug discovery. Secondary audience of undergraduate and graduate students taking courses in heterocyclic, medicinal chemistry and organic synthesis

Sarbani Pal is working as a faculty and head in the Department of Chemistry of M.N.R. Post-Graduate College in Hyderabad, India. Born in Kolkata, India, Dr. Pal began her university training at the University of Calcutta, where she obtained her M.Sc degree in Chemistry with specialization in Organic Chemistry in 1990. She subsequently moved to the Indian Association for the Cultivation of Science, Kolkata, India, where she worked under the guidance of Professor D. Mukherjee with a research fellowship (1991–1996) awarded by Council of Scientific and Industrial Research, New Delhi, India. She was awarded her Ph.D. degree by Jadavpur University, Kolkata, India, in 1996. She then moved to the Department of Chemistry, M.S. University, Baroda, Gujarat, India, where she worked as a Lecturer in Chemistry (1996–1997). Subsequently, she moved to Hyderabad, India, where she joined the M.N.R. Post-Graduate College as a Lecturer in Organic Chemistry. Her research interests include the total synthesis of bicyclic and tricyclic sesquiterpenes, synthesis of organo–ruthenium complexes, design and synthesis of anti-inflammatory agents and macrolide antibiotics. She has supervised several PhD students and published more than 50 research papers and review articles in various international journals. She was awarded Bioorganic and Medicinal Chemistry Letters Top 10 Cited Author for 2011-2012.
Manojit Pal received his M.Sc degree in Chemistry from the Indian Institute of Technology, Kharagpur, India in 1989 and PhD degree from Jadavpur University, Kolkata (India) in 1995. He then worked as a Research Officer-R&D in the Alembic Chemical Works Co Ltd. and as an Executive-Organic Synthesis in the Sun Pharma Advanced Research Centre. In 1998, he joined Dr. Reddy’s Laboratories Limited (DRL) in Hyderabad as a Senior Scientist and became Senior Director Discovery Chemistry in 2006. In 2007, he joined the New Drug Discovery Department of Matrix Laboratories Limited, Hyderabad as a Senior Gen
  • Features an overview of isocoumarins and their role in pharmaceutical research
  • Presents a template for the design, discovery and development of new and potential drugs in various therapeutic areas
  • Includes comprehensive coverage of the synthesis of isocoumarins, from traditional methods, to transition metal catalyzed methods
  • Looks at future applications for these important compounds in the areas of drug discovery and pharmaceutical research

Date de parution :

Ouvrage de 216 p.

15.2x22.8 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

187,99 €

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