Introduction to Translational Cardiovascular Research, 2015

Introduction – What Is Translational Research.- Insights into heart development and regeneration.- Basis Of Cell Excitability And Cardiac Conduction System.- The Renin-Angiotensin-Aldosterone System In Cardiovascular Diseases.- Beta adrenergic receptors.- The hypothalamic-pituitary-adrenal axis in human health and disease.- Genetic Polymorphisms.- Genetic Polymorphisms and the Vascular Endothelium.- The role of microRNAs in Cardiovascular Disease.- Pathways To Myocardial Hypertrophy.- The multiple actions of the insulin-like growth factor-I signaling in the myocardium.- Calcium Cycling Circuits in Cardiac Physiology and Pathophysiology.- Inflammation and atherosclerosis.- Stress proteins and the Adaptive Response of the Heart.- The Mechanisms And Modalities Of Cell Death.- Repair of the infarcted myocardium.- Pathways to cardiac remodeling.- A Translational Approach to Probe the Arrhythmic Potential of the Heart: Therapeutic Considerations.- Animal Models Of Cardiovascular Disease.- Experimental in vitro assessment of cardiac function.- In vivo experimental assessment of cardiac function.- Non invasive imaging modalities for Cardiovascular Translational Research- Technical Considerations.- Cardiovascular Applications of Non-Invasive Imaging in Cardiovascular Diseases: from Bench to Bedside.- Molecular Imaging of Inflammation Using Echoardiography: Advances With the Use of Microbubbles.- Clinical Aspects And Genetics Of Cardiomyopathies.- Cardiorenal Syndrome: What Basic Research Can Contribute.- Clinical aspects of Cardiorenal Syndrome: consequences of therapy with the Renin-Angiotensin System Inhibitors.- Pre-, Peri-, and Post-Conditioning the ischemic myocardium: Challenges, Confounders and Expectations.- Gene Therapy for the Heart.- Cell therapy in cardiac diseases.- Moving Towards a Novel Paradigm in Drug Development for Worsening Heart Failure: The T1 Model (Mechanistic Translational Phase).