Intrinsic Immunity, 2013 Current Topics in Microbiology and Immunology Series, Vol. 371

Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.

The APOBEC3 Family of Retroelement Restriction Factors

Eric W. Refsland and Reuben S. Harris

Inhibition of Retroviral Replication by Members of the TRIM Protein Family

Adam J Fletcher and Greg J Towers

The Antiviral Activities of Tetherin

Stuart J D Neil

Restriction of Retroviral Infection of Macrophages

Mark Sharkey

Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors

Welkin E. Johnson

RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants

Szittya György and József Burgyán

RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates

Arabinda Nayak, Michel Tassetto, Mark Kunitomi and Raul Andino

Roles of MicroRNAs in the Life Cycles of Mammalian Viruses

Eva Gottwein

Interplay Between DNA Tumor Viruses and the Host DNA Damage Response

Karyn McFadden and Micah Luftig

Written by leading experts in the field

Provides a better understanding of the co-evolution of viral pathogens and their hosts

Offers perspectives for the design of antiviral drugs

Includes supplementary material: sn.pub/extras