Intracellular Signal Transduction: The JAK-STAT Pathway, Softcover reprint of the original 1st ed. 1996 Coll. Molecular Biology Intelligence Unit
Langue : Français
Auteurs : Wilks Andrew F., Harpur Ailsa G.
This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
1. Intracellular Signal Transduction.- 2. The Cytokine Receptor Family.- 3. The JAK Family of Protein Tyrosine Kinases.- 4. Signal Transducers and Activators of Transcription: The STAT Proteins.- 5. STFs: STAT-Containing Transcription Factors.- 6. Somatic Cell Genetic Dissection of Interferon Signal Transduction Pathways.- 7. A Guided Tour Through the JAK-STAT Pathway.- 8. Hopscotch/Tumorous Lethal: A JAK Family Member from Drosophila melanogaster.- 9. Future Trends.- References.
Date de parution : 11-2013
Ouvrage de 209 p.
17.8x25.4 cm
Thèmes d’Intracellular Signal Transduction: The JAK-STAT Pathway :
Mots-clés :
Drosophila; cytokine; protein; receptor; signal transduction; transcription
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