Inhibitors of the Ras Superfamily G-proteins, Part B The Enzymes Series

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector InteractionFumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
2. An Orthosteric Inhibitor of the RAS-SOS InteractionSeth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
3. Conformation-Specific Inhibitors of Raf kinasesXiaolun Wang and Kristin Schleicher
4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant CancersLeanna Gentry, Ahmed A. Samatar and Channing J. Der
5. Inhibiting the RAS - PI3K Pathway in Cancer TherapyClare Sheridan and Julian Downward
6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras CancersJonathan M. Cooper, Brian O. Bodemann and Michael A. White
7. p21-Activated Kinase InhibitorsJoachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu
9. Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu and Ji Luo

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

• Informs and updates on all the latest developments in the field
• Contributions from leading authorities and industry experts