Immunobiology of Proteins and Peptides VIII, Softcover reprint of the original 1st ed. 1995 Manipulation or Modulation of the Immune Response Advances in Experimental Medicine and Biology Series, Vol. 383

This volume summarizes the proceedings of the Eighth International Symposium on the Immunobiology of Proteins and Peptides which was held on November 16-20 in Rio Rico, Arizona. The articles represent papers by invited speakers as well as papers selected by the Scientific Council, from among those submitted by the participants, on the basis of quality and timeliness. This symposium series was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings, discuss their significance in the light of current concepts and identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs would lead to the creation of a new generation of peptide reagents, which could have enormous potential in biological, therapeutic, and basic applications. This anticipated explosion has since occurred and many applications ofthese peptides are now being realized. The eighth symposium focused on the manipulation or modulation of the immune response. This volume broadly covers the areas of adjuvants, cytokines, vaccines, and the use of intravenous immunoglobulins for disease management. There is a clear need to identify methods for improving vaccine efficacy and guiding the host to respond with a particular type of immune response.

1. Silicone Gels as Adjuvants: Effects on Humoral and Cell-Mediated Immune Responses.- 2. The Effect of Molecular Weight and Gel Preparation on Humoral Adjuvancy of Silicone Oils and Silicone Gels.- 3. Glucans as Immunological Adjuvants.- 4. Copolymer Adjuvants.- 5. Regulation of 11-4 and 11-5 Secretion by Histamine and PGE2.- 6. Immunoglobulin Isotype Modulation after Administration of I1-12.- 7. Substance P Mediated Stimulation of Cytokine Levels in Cultured Murine Bone Marrow Stromal Cells.- 8. Malaria Transmission-Blocking Immunity: Identification of Epitopes and Evaluation of Immunogenicity.- 9.Experimental Feline Lyme Borreliosis as a Model for TestingBorreliaburgdorferiVaccines.- 10. Liposomal Vaccines.- 11. Protection Strategies against Botulinum Toxin.- 12. Collagen Arthritis in T Cell Receptor Congenic Mice: A Unique Approach to Study the Role of T Cell Receptor Genotypes in Autoimmune Arthritis.- 13. The Blood-Brain Barrier in Virus-Induced Demyelination.- 14. Idiotype Manipulation in Disease Management.- 15. Intravenous Immunoglobins (Ivigs) to Prevent and Treat Infectious Diseases.- 16. Qualitative and Quantitative Immune Response to Bacterial Capsular Polysaccharides and Their Conjugates in Mouse and Man.- 17. Autoimmune Recognition of Acetylcholine Receptor and Manipulation of the Autoimmune Responses by Synthetic Peptides.- 18. Amelioration of Autoimmune Reactions by Antigen-Induced Apoptosis of T Cells.- 19. Band 3 and Its Peptides during Aging, Radiation Exposure, and Alzheimer’s Disease: Alterations and Self-Recognition.- 20. Establishment of a Mouse Model of Myasthenia Gravis which Mimics Human Myasthenia Gravis Pathogenesis for Immune Intervention.- 21. Analysis of MHC-Specific Peptide Motifs: Applications in Immunotherapy.- 22. AutoantibodiesAgainst Peptide-Defined Epitopes of T-Cell Receptors in Retrovirally Infected Humans and Mice.- 23. Characterization of Autoantibodies Directed Against T Cell Receptors.- 24. Autoregulation of TCR V Region Epitopes in Autoimmune Disease.- 25. Influence of the Anterior Chamber of the EYE on T-Cell Production of Extracellular Antigen-Specific Proteins.- 26. The Development and Use of T Cell Receptor Peptide Vaccines.- 27. Evidence That Immunosuppression Is an Intrinsic Property of the Alpha-Fetoprotein Molecule.