Hepatitis C Virus: From Molecular Virology to Antiviral Therapy, 2013 Current Topics in Microbiology and Immunology Series, Vol. 369

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

The Origin of Hepatitis C Virus

Peter Simmonds

Cell Culture Systems for Hepatitis C Virus

Eike Steinmann and Thomas Pietschmann

Animal Models for Hepatitis C

Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss

Hepatitis C Virus Entry

Mirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert

Hepatitis C Virus Proteins: From Structure to Function

Darius Moradpour and François Penin

Hepatitis C Virus RNA Translation

Michael Niepmann

Hepatitis C Virus RNA Replication

Volker Lohmann

Virion Assembly and Release

Brett D. Lindenbach

Innate Immune Responses to Hepatitis C Virus

John W. Schoggins and Charles M. Rice

Adaptive Immune Responses in Hepatitis C Virus Infection

Christoph Neumann-Haefelin and Robert Thimme

Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

Daisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon

Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco

Treatment of Chronic Hepatitis C: Current and Future

Jean-Michel Pawlotsky

A comprehensive review

Written by leading experts

Richly illustrated

Includes supplementary material: sn.pub/extras