Handbook of Ion Channels
Coordonnateurs : Zheng Jie, Trudeau Matthew C.
The New Benchmark for Understanding the Latest Developments of Ion Channels
Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals.
Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs.
Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.
Basic Concepts. Ion Channel Methods. Ion Channel Families. Ion Channel Regulation. Ion Channel Physiology and Diseases. Index.
Jie Zheng, PhD, is a professor in the Department of Physiology and Membrane Biology at the University of California Davis School of Medicine. He earned a PhD in physiology from Yale University and received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington. Dr. Zheng has published over ten book chapters and review articles as well as numerous original research papers. His current research focuses on the activation mechanism of the temperature-dependent thermoTRP channels.
Matthew Trudeau, PhD, is an associate professor in the Department of Physiology at the University of Maryland School of Medicine. He earned a PhD in physiology from the University of Wisconsin-Madison and was a postdoctoral fellow at the University of Washington and the Howard Hughes Medical Institute (HHMI). Dr. Trudeau’s current work focuses on hERG potassium channels.
Date de parution : 10-2016
21x28 cm
Date de parution : 03-2015
Ouvrage de 671 p.
21x28 cm
Thèmes de Handbook of Ion Channels :
Mots-clés :
Io Nchannelfam; BK Channel; channelopathy; Ion Channel; structure-function relationship; Selectivity Lter; nervous system; Kv Channels; membrane excitability; CNG Channel; ligand; Trp Channel; ion channel-related disease; Ncep Ts; ion channel properties; TRPC Channel; ion channel types; K2P Channel; sensory stimuli; CaV Channels; electrical properties of neurons and cardiac cells; DRG Neuron; CFTR Channel; Gating Charge; AMPA Receptor; BK Channel Activation; Voltage Sensors; KCNQ1 Channel; ENaC; MWC Model; MSD; NaV Channels; Cys Loop Receptors; S6 Helix; Bartter’s Syndrome