Glycoimmunology 2, Softcover reprint of the original 1st ed. 1998 Advances in Experimental Medicine and Biology Series, Vol. 435

The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.

Glycobiology: The Basics.- Novel Pathways in Complex-Type Oligosaccharide Synthesis: New Vistas Opened by Studies in Invertebrates.- Defective Glycosyltransferases Are Not Good for Your Health.- Probing Carbohydrate-Protein Interactions by High-Resolution NMR Spectroscopy.- Oligosaccharides and Protein Recognition.- The Structure of a Human Rheumatoid Factor Bound to IgG Fc.- Carbohydrate Recognition Systems in Innate Immunity.- Biosynthesis of Sulfated L-Selectin Ligands in Human High Endothelial Venules (HEV).- Endothelial Sialyl Lewis x as a Crucial Glycan Decoration on L-Selectin Ligands.- Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasion.- Oligosaccharides and Biological Function.- Protein O-GlcNAcylation: Potential Mechanisms for the Regulation of Protein Function.- A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myeloma.- The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Quality Control.- Glycosylation and Inflammation.- Immunodetection of Glycosyltransferases: Prospects and Pitfalls.- Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity.- Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins.- Glycosylation and Disease.- The Glycosylation of the Complement Regulatory Protein, Human Erythrocyte CD59.- Glycosylation and Rheumatic Disease.- IgA Glycosylation in IgA Nephropathy.- Oligosaccharide Profiling of Acute-Phase Proteins: A Possible Strategy towards Better Markers in Disease.- The Role of N-Linked Glycosylation in the Secretion of Hepatitis B Virus.- Role of Glycan Processing in Hepatitis B Virus Envelope Protein Trafficking.- Glycotherapeutics.- Combinatorial Carbohydrate Chemistry.- Bacterial Lipopolysaccharides: Candidate Vaccines to Prevent Neisseria meningitidis and Haemophilus influenzae Infections.- Development of Double Copy Dicistronic Retroviral Vectors for Transfer and Expression of Glycosyltransferase Genes.- Oligosaccharide Epitope Diversity and Therapeutic Potential.- The Group B Streptococcal Capsular Carbohydrate: Immune Response and Molecular Mimicry.