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Genetic Variants in Alzheimer's Disease, 2013

Langue : Anglais

Coordonnateurs : Morgan Kevin, Carrasquillo Minerva M.

Couverture de l’ouvrage Genetic Variants in Alzheimer's Disease
Alzheimer?s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer?s Disease has made significant advances; in fact, one could argue more than in the previous two decades.  This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer?s.  These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.  The aim of this book is to put all of the recent genetic data on these new genes into context.  Different genetic variants will be discussed, as well as biomarkers and future possibilities. ?

The Genetics of Alzheimer’s disease: Introduction and Perspective for the Future.- Apolipoprotein E .- Clusterin.- PICALM.- Complement Component (3b/4b) Receptor 1(CR1).- Bridging Integrator 1 (BIN1).- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7).- Membrane-spanning 4-domains subfamily A, MS4A cluster.- Sialic acid binding immunoglobulin-like lectin-3 (CD33).- Erythropoietin-producing human hepatocellular carcinoma (EphA1).- CD2-associated protein (CD2AP).- Other Genes Implicated in Alzheimer’s Disease.- The Future Role of Biomarkers in Alzheimer’s Disease Diagnostics.- Index.

The aim of this book is to put all of the recent genetic data on these new genes into context

New genetics of Alzheimer’s disease

Different genetic variants are discussed, as well as biomarkers and future possibilities ?

Includes supplementary material: sn.pub/extras

Date de parution :

Ouvrage de 254 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 158,24 €

Ajouter au panier

Date de parution :

Ouvrage de 254 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 158,24 €

Ajouter au panier

Thème de Genetic Variants in Alzheimer's Disease :