Fundamentals of Biochemistry (6^th Ed.)

Fundamentals of Biochemistry, 6th Edition, with new author team Destin Heilman and Stephen Woski, is fully updated for focus, readability, and currency.

This revision provides students with a solid biochemical foundation rooted in chemistry and prepares them for future scientific challenges. Its pedagogical focus remains on biochemistry's key theme: the relationship between structure/function. The text?s foundation demonstrates the relationships between the monomeric units (amino acids, monosaccharides, nucleotides, and fatty acids) and the biomolecular structures they form.

The new authors continue the trusted pedagogy of the previous five editions and present approachable, balanced coverage relevant to human health and disease. Fundamentals of Biochemistry 6e includes new, stunning, and enhanced visuals and new measurable learning objectives in each chapter section that offer a practical pathway for student learning and understanding.

1 Introduction to the Chemistry of Life

The Origin of Life

Cellular Architecture

Thermodynamics

Problems

2 Water

Physical Properties of Water

Chemical Properties of Water

Problems

3 Amino Acids

Amino Acid Structure

Stereochemistry

Amino Acid Derivatives

Polypeptides and Proteins

Problems

4 Proteins: Three-Dimensional Structure

Secondary Structure

Tertiary Structure

Quaternary Structure and Multiprotein Complexes

Protein Folding and Unfolding

Biochemistry in Focus: Oxygen Transport

Problems

5 Carbohydrates

Monosaccharides

Polysaccharides

Glycoproteins

Problems

6 Nucleotides, Nucleic Acids, and Genetic Information

Nucleotides and Polynucleotides

Nucleic Acid Structure: DNA

Nucleic Acid Structure: RNA

Problems

7 Lipids and Biological Membranes

Lipid Classification

Lipid Bilayers

Membrane Proteins

Membrane Structure and Assembly

Problems

8 Membrane Transport

Thermodynamics of Transport

Passive-Mediated Transport

Active Transport

Problems

9 Enzymatic Catalysis

General Properties of Enzymes

Enzymes Work by Lowering Activation Energy

Mechanisms

Lysozyme

Serine Proteases

Problems

10 Enzyme Kinetics, Inhibition, and Control

Reaction Kinetics

Enzyme Inhibition

Control of Enzyme Activity

Biochemistry In Focus: Enzymes as Targets for Drug Design

Problems

11 Biochemical Signaling

Hormones

Receptor Tyrosine Kinases

Heterotrimeric G Proteins

The Phosphoinositide Pathway

Biochemistry in Focus: Chemical Signaling and Movement

Problems

12 Introduction to Metabolism

Overview of Metabolism

"High-Energy" Compounds

Oxidation–Reduction Reactions

Experimental Approaches to the Study of Metabolism

Problems

13 Glucose Catabolism

Overview of Glycolysis

The Reactions of Glycolysis

Metabolism of Hexoses Other than Glucose

Fermentation: The Anaerobic Fate of Pyruvate

Gluconeogenesis

Regulation of Glycolysis and Gluconeogenesis

The Pentose Phosphate Pathway

Problems

14 Glycogen Metabolism and Gluconeogenesis

Glycogen Breakdown

Glycogen Synthesis

Control of Glycogen Metabolism

Other Carbohydrate Biosynthetic Pathways

Problems

15 Citric Acid Cycle

Overview of the Citric Acid Cycle

Synthesis of Acetyl-SCoenzyme A

Enzymes of the Citric Acid Cycle

Regulation of the Citric Acid Cycle

Reactions Related to the Citric Acid Cycle

Problems

16 Electron Transport and Oxidative Phosphorylation

The Mitochondrion

Electron Transport

Oxidative Phosphorylation

Control of Oxidative Metabolism

Biochemistry in Focus: The Mitochondrion and Cell Death

Problems

17 Photosynthesis

Chloroplasts

The Light Reactions

The Dark Reactions

Problems

18 Lipid Metabolism

Lipid Digestion, Absorption, and Transport

Fatty Acid Oxidation

Fatty Acid Biosynthesis

Synthesis of Other Lipids

Cholesterol Metabolism

Problems

19 Amino Acid Metabolism

Protein Degradation

Amino Acid Deamination and the Urea Cycle

Breakdown of Amino Acids

Amino Acid Biosynthesis

Other Products of Amino Acid Metabolism

Biochemistry in Focus: Nitrogen Fixation

Problems

20 Mammalian Fuel Metabolism: Integration & Regulation

Organ Specialization

Hormonal Control of Fuel Metabolism

Metabolic Homeostasis: The Regulation of Energy Metabolism, Appetite, and Body Weight

Disturbances in Fuel Metabolism

Problems

21 Nucleotide Metabolism

Synthesis of Purine Ribonucleotides

Synthesis of Pyrimidine Ribonucleotides

Formation of Deoxyribonucleotides

Nucleotide Degradation

Problems

22 DNA Replication

Overview of DNA Replication

Prokaryotic DNA Replication

Eukaryotic DNA Replication

Problems

23 DNA Repair and Recombination

DNA Damage

DNA Repair

Recombination and Transposons

Problems

24 Transcription and RNA Processing

Prokaryotic RNA Transcription

Transcription in Eukaryotes

Posttranscriptional Processing

Problems

25 Protein Synthesis

The Genetic Code

Transfer RNA and Its Aminoacylation

Ribosomes

Translation

Posttranslational Processing

Problems

26 Regulation of Gene Expression

Genome Organization

Regulation of Prokaryotic Gene Expression

Regulation of Eukaryotic Gene Expression

The Cell Cycle, Cancer, Apoptosis, and Development

Appendix: Methods