Flavonoids in the Living System, Softcover reprint of the original 1st ed. 1998 Advances in Experimental Medicine and Biology Series, Vol. 439

The presence of contaminant flavonoids in vitamin C preparations from citrus fruits initially led Szent-Gyorgyi and his collaborators to suggest that a flavonoid compound, with biological activity for the prevention of capillary fragility, was vitamin P. Later re­ search, although not disproving biological activity, discontinued the use of the vitamin classification for these compounds. However, the ubiquitous distribution of flavonoids in living organisms, and the continued discovery of various activity in biological systems makes these compounds targets of wide ranging investigation. This volume is primarily based on a Symposium on Flavonoids and related com­ pounds held during the 212th National Meeting of the American Chemical Society held in Orlando, Florida on August 28-29, 1996 under the sponsorship of the Division of Agricul­ tural and Food Chemistry. While the book is not intended to be a comprehensive volume on flavonoid research, the papers provide various approaches to exploring the biological functions of flavonoids in plants and animals, their chemical modifications for enhanced activity, some analytical techniques, as well as their use in food classification. A signifi­ cant portion is devoted to medicinal implications of these compounds. The organizers would like to express their appreciation to Tropicana Products, Inc., Bradenton, Florida, Coca-Cola Foods Division, Plymouth, Florida and the American Chemical Society's Division of Agricultural and Food Chemistry for financial support. Of course, the book could not be produced without the authors, whose cooperation and pa­ tience is greatly appreciated.

1. Flavonoids in the Living System: An Introduction.- 2. Flavonoids and Arbuscular-Myeorrhizal Fungi.- 3. The Role of Glycosylation in Flavonol-Induced Pollen Germination.- 4. Expression of Genes for Enzymes of the Flavonoid Biosynthetic Pathway in the Early Stages of the Rhizobium-Legume Symbiosis.- 5. Prospects for the Metabolic Engineering of Bioactive Flavonoids and Related Phenylpropanoid Compounds.- 6. Flavonoid Accumulation in Tissue and Cell Culture: Studies in Citrus and Other Plant Species.- 7. Flavonoids of the Orange Subfamily Aurantioideae.- 8. Citrus Flavonoids: A Review of Past Biological Activity Against Disease: Discovery of New Flavonoids from Dancy Tangerine Cold Pressed Peel Oil Solids and Leaves.- 9. Differentiation of Soy Sauce Types by HPLC Profile Pattern Recognition: Isolation of Novel Isoflavones.- 10. Induction of Oxidative Stress by Redox Active Flavonoids.- 11. Flavonoids in Foods as in Vitro and in Vivo Antioxidants.- 12. Antithrombogenic and Antiatherogenic Effects of Citrus Flavonoids: Contributions of Ralph C. Robbins.- 13. Effect of Plant Flavonoids on Immune and Inflammatory Cell Function.- 14. Flavonoids: Inhibitors of Cytokine Induced Gene Expression.- 15. Recent Advances in the Discovery and Development of Flavonoids and Their Analogues as Antitumor and Anti-HIV Agents.- 16. Inhibition of Mammary Cancer by Citrus Flavonoids.- 17. Inhibition of Neoplastic Transformation and Bioavailability of Dietary Flavonoid Agents.- 18. Flavonoids as Hormones: A Perspective from an Analysis of Molecular Fossils.