Flavonoid Pharmacokinetics

Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples, Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical–derived compounds. The book uses applicable examples in different preclinical species and humans to strengthen pharmacokinetic concepts and to demonstrate how they apply on the preclinical and clinical drug development process.

Foreword ix Preface xiii Contributors xv 1 Polyphenols and Flavonoids: An Overview 1 Jaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega–Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies 2 Analysis of Flavonoids through Chromatography 71 Jody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies 3 Chiral Methods of Flavonoid Analysis 117 Jaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies 4 Preclinical Pharmacokinetics of Flavonoids 161 Jaime A. Yáñez, Casey L. Sayre, and Neal M. Davies 5 Clinical Pharmacokinetics of Flavonoids 195 Casey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies 6 Toxicology and Safety of Flavonoids 249 Stephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds 7 Flavonoids and Drug Interactions 281 Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. Davies Index 321