Estrogens, Progestins and their Antagonists, Softcover reprint of the original 1st ed. 1997 Two-Volume SET Hormones in Health and Disease Series

These two volumes on Estrogens, Progestins, and Their Antagonists repre­ sent a thematic extension of the series, Hormones in Health and Disease. The first publication in the series, Steroid Hormone Receptors: Basic and Clinical Aspects, focused on recent advances in the anatomy of steroid receptors and members of the steroid receptor superfamily. Consistent with the spirit of the series, the authors addressed issues of clinical significance of steroid receptor detection in hormone-related disorders. The second volume in the series, Hormones and Cancer, attempted a more direct examination of ac­ tions of hormones in cancerous tissues and cells. In these two volumes, which together form the third in the series, the editor, Dr. Edward Pavlik, has introduced a team of leading investigators engaged in research on various aspects of the steroids that regulate female reproductive physiology. Estrogens and progestins, the main components of the most widely used contraceptive pills, have found a variety of uses in clinical endocrinology. These volumes contain discussions that range from the introduction of novel hormonal ligands to hormonal antagonism by steroid analogs. A balanced treatment is provided of applications of the steroids in treatment and management of hormone-dependent conditions and malignancies. The remarkable synthesis of literature contained in this volume will provide a reader with both the fundamental concepts underly­ ing steroid hormone physiology and the clinical applications of observations made on basic aspects of hormone action. I congratulate the editorial leadership of Dr.

I: New Applications and Concepts Involving Estrogens and Progestins.- 1. Benefits and Risks of Hormone Replacement Therapy.- 2. Phytoestrogen Effects in Humans Relative to Risk for Cardiovascular Disease, Breast Cancer, Osteoporosis, and Menopausal Symptoms.- 3. Dietary Indoles with Antiestrogenic Activity in Common Vegetables and Their Implications.- 4. Treatment for Infertility and Risk of Female Cancers.- 5. Antiestrogen Resistance in Human Breast Cancer.- 6. Evolving Therapies for Prostatic Carcinoma, Encompassing Orchiectomy, Estrogens, and Estramustine.- 7. Regulatory Aspects of Estrogens and Progestins in Human Food: Past, Present, and Future.- II: Novel Hormonal Ligands.- 8. Estrogen and Progestin Radiopharmaceuticals for Imaging Breast Cancer.- 9. The Utility of Fluorescent Estrogens for Receptor Imaging.- 10. Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel and Gestodene and Older Oral Contraceptives.- 11. Antiprogestins: Past, Present, and Future.- I: Estrogen and Progestin Physiological Function.- 1. Pituitary and Brain Actions of Estrogen and Progesterone in the Regulation of Primate Prolactin Secretion.- 2. Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors.- 3. Physiological Findings from Transgenic Mouse Models with Altered Levels of Estrogen Receptor Expression.- II: Molecular Biology of Steroid Receptors and Gene Expression.- 4. New Models and Insights in Steroid Hormone Action.- 5. A Role for Progesterone in Multidrug Resistance.- 6. Dominant Negative Activity by Estrogen and Progesterone Receptors.- 7. Estrogen and Progesterone Receptors in Human Endometrial Cancer.- III: Factors Enhancing Receptor Function.- 8. Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group Protein-1: Protein Manipulation of DNA Structure.- 9. Use of FK506 and Its Analogs in Studying Progesterone Signaling.- Keyword Index.- Keyword Index.