Essentials of Medical Biochemistry (3^rd Ed.) With Clinical Cases

Essentials of Medical Biochemistry, Third Edition offers a condensed, yet detailed overview of clinical biochemistry, spanning fundamentals and relevant physiologic and pathophysiologic concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis.

Users will find fundamental concepts aiding students and professionals in biochemistry, medicine, and other healthcare disciplines. The text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists.

This Third Edition has been fully updated to address evolving techniques in the biological sciences, including genomics, metabolomics, transcriptomics, epigenomics, proteomics, and gene therapy, among other methods. In addition, each chapter has been fully revised for current science and now features learning objectives and chapter summaries, supplemental reading, and 5 clinical case based multiple choice questions. New clinical cases have been added throughout.

1. The Human Organism: Organ Systems, Cells, Organelles, and Our Microbiota 2. Water, Acids, Bases, and Buffers 3. Amino Acids 4. Three-Dimensional Structure of Proteins and Disorders of Protein Misfolding 5. Energetics of Biological Systems, Enzymes and Enzyme Regulation 6. Clinical Enzymology and Biomarkers of Tissue Injury 7. Simple Carbohydrates 8. Heteropolysaccharides: Glycoconjugates, Glycoproteins, and Glycolipids 9. Connective Tissue: Fibrous and Nonfibrous Proteins and Proteoglycans 10. Gastrointestinal Digestion and Absorption 11. Carbohydrate Metabolism I: Glycolysis and the Tricarboxylic Acid Cycle 12. Electron Transport Chain, Oxidative Phosphorylation, and Other Oxygen-Consuming Systems 13. Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways 14. Protein and Amino Acid Metabolism 15. Lipids I: Fatty Acids and Eicosanoids 16. Lipids II: Phospholipids, Glycosphingolipids, and Cholesterol 17. Lipids III: Plasma Lipoproteins 18. Contractile Systems 19. Perturbations of Energy Metabolism: Obesity and Diabetes Mellitus 20. Structure and Properties of DNA 21. DNA Replication, Repair, and Mutagenesis 22. RNA and Protein Synthesis 23. Regulation of Gene Expression 24. Nucleotide Metabolism 25. Hemoglobin and Metabolism of Iron & Heme 26. Endocrine Metabolism I: Introduction and Signal Transduction 27. Endocrine Metabolism II: Hypothalamus and Pituitary 28. Endocrine Metabolism III: Adrenal Glands 29. Endocrine Metabolism IV: Thyroid Gland 30. Endocrine Metabolism V: Reproductive System 31. Immunology 32. Biochemistry of Hemostasis 33. Mineral Metabolism 34. Vitamin Metabolism 35. Drug Metabolism

at the John A. Burns School of Medicine, University of Hawaii at Manoa. Since 2001,

he has been teaching medical biochemistry to students who come from disadvantaged

backgrounds. He is also actively involved in the various aspects of molecular biology

and biochemical research in the field of clinical medicine.
N. V. Bhagavan is an Emeritus Professor in the department of Anatomy, Biochemistry,

and Physiology at the John A. Burns School of Medicine, University of Hawaii at Manoa.

An active professor, researcher, and teacher, he has many years of experience in both

the instruction and practice of clinical biochemistry.

• Integrates the biochemical principles with physiological, pharmacological, and pathological aspects of human diseases
• Each chapter features learning objectives, summaries, required and supplemental reading lists, clinical cases, and multiple-choice questions
• Presents essential biochemical concepts within the context of their biological functions Offers instructional overview figures, flowcharts, tables and multi-colored illustrations
• Provides an online ancillary package with PowerPoint images and an additional 500 study questions to aid in comprehension and USMLE exam preparation