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Essential Pharmacokinetics A Primer for Pharmaceutical Scientists

Langue : Anglais

Auteur :

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

Preface

Chapter 1 - IntroductionChapter 2 – Basic Concepts of PharmacokineticsChapter 3 - Physicochemical Properties and PharmacokineticsChapter 4 - Drug Pharmacokinetics After Alternative Routes of AdministrationChapter 5 - Pharmacologic Response and Drug Dosage AdjustmentsChapter 6 - The Effect of Food and Exipients on Drug PharmacokineticsChapter 7 - Practice Problems

Appendix I: Answers to Problems in Chapter 7Appexndix II: Symbols and Abbreviations

Intended for graduate students and pharmaceutical scientists involved in self-study of the topic or tutored classes in pharmacokinetics, specifically those in non-clinical health-related sciences such as pharmaceutics, drug formulation and medicinal chemistry.
Dr. Thorsteinn Loftsson is a Professor of Physical Pharmacy at the University of Iceland in Reykjavik. He received his MS Pharm degree from University of Copenhagen and his MS and PhD degrees from the Department of Pharmaceutical Chemistry at the University of Kansas. Dr. Loftsson has authored or co-authors over 200 papers in peer-reviewed journals, numerous book chapters and 20 patents and patent applications. His main research areas include the pharmaceutical applications of cyclodextrins, marine lipids, prodrugs and soft drugs. He has conducted over 100 lectures and is a Fellow of the American Association of Pharmaceutical Scientists (AAPS). Dr. Loftsson is also a member for the editorial board of Journal of Pharmaceutical Sciences, International Journal of Pharmaceutics, Journal of Pharmacy and Pharmacology, die Pharmazie and Journal of Drug Delivery Science and Technology (formerly STP Pharma Sciences).
  • Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products
  • Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes
  • Illustrates how to write and evaluate drug registration files