Epithelial Transport Physiology, 2010

Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1?6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7?16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.

Chloride ATPase Pumps in Epithelia.- Divalent Anion Transport in Crustacean and Molluscan Gastrointestinal Epithelia.- Heavy Metal Transport and Detoxification by Crustacean Epithelial Lysosomes.- Epithelial Calcium Transport in Crustaceans: Adaptation to Intrinsic and Extrinsic Stressors.- The Cellular Basis of Extreme Alkali Secretion in Insects: A Tale of Two Tissues.- H+, Na+, K+, and Amino Acid Transport in Caterpillar and Larval Mosquito Alimentary Canal.- CFTR-Dependent Anion Transport in Airway Epithelia.- Sulfate and Phosphate Transporters in Mammalian Renal and Gastrointestinal Systems.- Role of H+-K+ ATPase, Na+-K+-2Cl? and Na+-Cl?-HCO3 ? Transporters in Vertebrate Small Intestine.- The H+- and H+, K+-ATPases of the Collecting Duct.- Acid/Base Regulation in Renal Epithelia by H,K-ATPases.- Sodium Transport Mechanisms in the Mammalian Nephron.- Renal Acid–Base Regulation Via Ammonia Transport in Mammals.- Hexose Transport Across Mammalian Epithelia.- Amino Acid Transport by Epithelial Membranes.- Molecular Ontology of Amino Acid Transport.

The diversity of organisms from invertebrate to vertebrate telescopes possible evolutionary trends in a given transport process The diversity of transporters in various animal epithelia inductively traces the adaptive response of the specific animal in regards to its environmental pressures Speculation as to how epithelial transporters came to exist after the "Big Bang" created our universe Includes supplementary material: sn.pub/extras