Epigenetic Pharmacology and Therapeutics

Epigenetic Pharmacology and Therapeutics highlights the interface between epigenetics and pharmacology by examining the role of epigenetics in the regulation of ADME genes and metabolism and delineating the importance of epigenetic enzymes in nuclear receptors signaling. This book discusses in detail the current trends in epigenetic therapy in cancer, epigenetic modifications and neurological disorders and epigenetic mechanisms in inflammation. A valuable guide for researchers and students interested in epigenetic pharmacology, this book provides new insight into the emerging role of epigenetic alterations as predictors of drug responses and potential tools to further drug therapy.

• Outlines the molecular mechanism of action of epigenetic drugs and their mechanism of resistance
• Highlights RNA interference and epigenetics in drug discovery
• Reviews the current status of epigenetic drugs in clinical trials
• Covers epigenetic biomarkers as new tools in current epigenetic and future drug therapy

Chapter 1 - Introduction to Epigenetics Chapter 2 - Epigenetics Regulation of Nuclear Receptors and Transcriptional Factors Chapter 3 - The Role of Epigenetics in Drug Responses Chapter 4 - Epigenetic Treatments in Cancer Chapter 5 - Epigenetic Modifications and Neurological Disorders: Potential Therapies Chapter 6 - Epigenetic Mechanisms in Inflammation Chapter 7 - Current Epigenetic Drugs in Clinical Trials Chapter 8 - Epigenetic Biomarkers Chapter 9 - Conclusions and Future Directions