Endothelin Receptors and Signaling Mechanisms, Softcover reprint of the original 1st ed. 1998

Was geschieht in Zellen, wenn die Endothelin-Rezeptoren aktiviert werden? This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.

1. Introduction to the Endothelin System.- 2. Endothelin Receptors and Receptor Antagonists.- 3. Novel Endothelin Receptors.- 4. “Sticky” Conundrums in the Endothelin System: Unique Binding Characteristics of Receptor Agonists and Antagonists.- 5. Functional Coordination and Cooperation Between Endothelin and Nitric Oxide Systems in Vascular Regulation.- 6. Molecular and Structural Biology of Endothelin Receptors.- 7. Cytokine Regulation of Endothelin Action.- 8. Endothelin Modulation of Renal Sodium and Water Transport.- 9. Endothelin and Ion Channels.- 10. Endothelin and Calcium Signaling.- 11. Endothelin Regulation of Cardiac Contractility: Signal Transduction Pathways.- 12. Endothelin Signaling to the Nucleus: Regulation of Gene Expression and Phenotype.- 13. Mechanisms of Endothelin-induced Mitogenesis and Activation of Stress Response Protein Kinases.- Color Insert.

Was geschieht in Zellen, wenn die Endothelin-Rezeptoren aktiviert werden?