Endogenous ADP-Ribosylation, Softcover reprint of the original 1st ed. 2015 Current Topics in Microbiology and Immunology Series, Vol. 384

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:

·   Evolution and detection of endogenous ADP-ribosylation

·   ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)

·   ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)

The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Part I: Evolution and Detection of Endogenous ADP-Ribosylation

The natural history of ADP-ribosyltransferases and the ADP ribosylation system

L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer

Identification and Analysis of ADP-ribosylated Proteins

Friedrich Haag and Friedrich Buck

Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)

Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine

Klaus Aktories, Gudula Schmidt and Alexander E. Lang

Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein

Hideaki Tsuge, Toshiharu Tsurumura

Regulation of nitrogenase by reversible mono-ADP-ribosylation

Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells

Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch

Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish

Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe

Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family

Ana Filipa Pinto and Herwig Schüler

Function and regulation of the mono-ADP-ribosyltransferase ARTD10

Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher

Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15

Maria Di Girolamo

Broadens your understanding of endogenous mono-ADP-ribosylation reactions

Brings together exciting recent findings on ADP-ribosylation

Written by leading experts in the field

Includes supplementary material: sn.pub/extras