Drugs of Abuse, Immunity, and AIDS, Softcover reprint of the original 1st ed. 1993 Advances in Experimental Medicine and Biology Series, Vol. 335

This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine with financial assistance from the National Institute on Drug Abuse. The focus of this conference was the effects of drugs of abuse on immunity. It is now widely recognized that psychoactive drugs of abuse, including marijuana, cocaine, and opiates, as well as alcohol, have marked effects in an individual, including effects on their nervous system and behavior. In the past two decades, the scope of studies concerning the effects of some drugs of abuse have also involved investigations of alterations of various physiologic parameters including effects on the immune system. and the influence of such immune alterations on normal physiological responses. In this regard, participants in this Second International Conference provided newer information concerning both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiencies. In this regard, advances have been made in recent years concerning the nature and mechanisms whereby the immune system is regulated and the possible mechanisms by which drugs of abuse influence such immune systems. In particular, the emergence of psychoneuroimmunology as a new discipline the last decade has heightened interest in the immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving both clinical and basic scientists, including microbiologists, immunologists, physiologists, psychiatrists, oncologists, psychologists, etc.

Stress, the Hypothalamic-Pituitary-Adrenal Axis, and Immune Function.- Psychological Stress, Immunity, and Immune Depression.- Opioids, Receptors, and Immunity.- Consequences of Opiate-Dependency in a Monkey Model of AIDS.- Effects of Opioids on Proliferation of Mature and Immature Immune Cells.- Immune Alterations in Chronic Morphine-Treated Rhesus Monkeys.- Immunosuppressive Effects of Morphine on Immune Responses in Mice.- Morphine-Induced Modulation of Immune Status: Evidence for Opioid Receptor Mediation and Compartment Specificity.- Morphine Binding Sites on Human T Lymphocytes.- Marijuana and Bacterial Infections.- Effects of Marijuana on Spleen Lymphocytes from Mice of Different Age Groups.- Syphilis and Drugs of Abuse.- Serum Proteins Affect the Inhibition by Delta-Tetrahydrocannabinol of Tumor Necrosis Factor Alpha Production by Mouse Macrophages.- Marijuana and Host Resistance to Herpesvirus Infection.- Marijuana and Head and Neck Cancer.- Evidence for a Cannabinoid Receptor in Immunomodulation by Cannabinoid Compounds.- Cocaine and Immunocompetence: Possible Role of Reactive Metabolites.- Molecular Mechanisms Associated with Cocaine-Induced Modulation of Human T Lymphocytes Proliferation.- Effects of Cocaine on the Respiratory Burst of Murine Macrophages.- Cocaine Facilitation of Cryptosporidiosis by Murine AIDS in Male and Female C57/BL/6 Mice.- Ethanol-Induced Suppression of in Vivo Host Defense Mechanisms to Bacterial Infection.- Alcohol, Cytokines, and Immunodeficiency.- Human Polymorphonuclear Leukocyte (PMN) Priming/Activation by Acute Ethanol Intoxication.- Ethanol Affects Macrophage Production of IL-6 and Susceptibility to Infection by Legionella pneumophila.- Suppression by Dietary Alcohol of Resistance to Cryptosporidium During Murine Acquired Immune Deficiency Syndrome.- Enhancement of HIV-1 Replication by Opiates and Cocaine: The Cytokine Connection.- Small Animal Model of AIDS and the Feline Immunodeficiency Virus.- Current Status and Future Prospects in the Immunotherapy of Human Immunodeficiency Virus (HIV) Infection.- Perinatal AIDS: Drugs of Abuse and Transplacental Infection.- Solid Tumors and HIV-Infected Patients Other Than AIDS-Defining Neoplasms.- Stress, Endocrine Responses, Immunity and HIV-1 Spectrum Disease.- Epidemiology and Infectious Complications of Human Immunodeficiency Virus Antibody Positive Patients.- Immune Function and Drug Treatment in Anti-Retrovirus Negative Intravenous Drug Users.- Psychosocial Stress and NK Cells among Members of a Communal Settlement.- Multiple Pathogens May Induce Growth Factor Cascade Resulting in KS.- Exposure to the Abused Inhalant, Isobutyl Nitrite, Compromises both Antibody and Cell-Mediated Immunity.- Natural Killer Cells and Cryptococcus neoformans.