Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays (2nd Ed., 2nd ed. 2013)
Coordonnateurs : Vogel H. Gerhard, Maas Jochen, Hock Franz J., Mayer Dieter
-A landmark in the continuously changing world of drugs
-Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
-Of use for government institutions and committees working on official guidelines for drug evaluation worldwide
Safety Pharmacokinetics
Absorption / in vitro Tests / Cell Based
Absorption / in vitro Tests / Non Cell Based
Absorption / in vivo Tests (Radiolabeled)
Bioanalytical Assays - RIA/EIA
Bioanalytical Assays / Gas Chromatography (GC)
Bioanalytical Assays / LC-MS/MS
Bioanalytical Assays / Toxicokinetics
Clinical Studies / Typical Designs
Distribution - Across Barriers
Distribution - in vivo - Perfused Organs
Distribution / in vitro Tests / Protein Binding
Distribution / in vivo / Other Methods
Distribution in vivo
Drug-drug Interaction / Enzyme Induction
Drug-drug Interaction / Enzyme Inhibition
In silico ADME Modeling
Metabolism Studies in vitro and in vivo
Pharmacogenomics in DME
Physicochemical Properties
Population Pharmacokinetics
Safety Pharmacokinetics: Introduction
Typical PK/PD Approaches in Preclinical and Clinical Development
Safety Pharmacology
Analgesic Activity and Intravenous and Inhalation Anesthetics
Anti-inflammatory and Antiarthrotic Activity
Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells
Blood Constituents
Cardiovascular Pharmacology
Central Nervous System
Chronobiology and the Implications for Safety Pharmacology
Cochlear Safety Tests
Drug Safety on Herbal Medical Products
Drug-Addiction and Drug-Dependency
Endocrine Pharmacology
Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment
Metabolism Pharmacology
Ocular Safety Tests
Oncology Pharmacology
Peripheral Nervous System
Pulmonary Pharmacology
Renal System
Safe Chemicals / REACH
Safety Pharmacology in Biologics, Antibiotics and Monoclonics
Safety Pharmacology: Introduction and Guidelines
Sensory Systems
Skin Pharmacology
Stem Cells in Safety Pharmacology
Study design and statistics
Transgenic Animals
Zebrafish Model
Safety Toxicology
Genotoxicity
In silico Methods
In vitro toxicity testing
International Guidelines
OMICS Technologies
Reproductive Toxicology
Safety Toxicology: Introduction
Testing of Medical Devices
Testing of Monoclonal Antibodies
Toxicogenomics
Absorption / in vitro Tests / Non Cell Based
Absorption / in vivo Tests (Radiolabeled)
Bioanalytical Assays - RIA/EIA
Bioanalytical Assays / Gas Chromatography (GC)
Bioanalytical Assays / LC-MS/MS
Bioanalytical Assays / Toxicokinetics
Clinical Studies / Typical Designs
Distribution - Across Barriers
Distribution - in vivo - Perfused Organs
Distribution / in vitro Tests / Protein Binding
Distribution / in vivo / Other Methods
Distribution in vivo
Drug-drug Interaction / Enzyme Induction
Drug-drug Interaction / Enzyme Inhibition
In silico ADME Modeling
Metabolism Studies in vitro and in vivo
Pharmacogenomics in DME
Physicochemical Properties
Population Pharmacokinetics
Safety Pharmacokinetics: Introduction
Typical PK/PD Approaches in Preclinical and Clinical Development
Safety Pharmacology
Analgesic Activity and Intravenous and Inhalation Anesthetics
Anti-inflammatory and Antiarthrotic Activity
Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells
Blood Constituents
Cardiovascular Pharmacology
Central Nervous System
Chronobiology and the Implications for Safety Pharmacology
Cochlear Safety Tests
Drug Safety on Herbal Medical Products
Drug-Addiction and Drug-Dependency
Endocrine Pharmacology
Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment
Metabolism Pharmacology
Ocular Safety Tests
Oncology Pharmacology
Peripheral Nervous System
Pulmonary Pharmacology
Renal System
Safe Chemicals / REACH
Safety Pharmacology in Biologics, Antibiotics and Monoclonics
Safety Pharmacology: Introduction and Guidelines
Sensory Systems
Skin Pharmacology
Stem Cells in Safety Pharmacology
Study design and statistics
Transgenic Animals
Zebrafish Model
Safety Toxicology
Genotoxicity
In silico Methods
In vitro toxicity testing
International Guidelines
OMICS Technologies
Reproductive Toxicology
Safety Toxicology: Introduction
Testing of Medical Devices
Testing of Monoclonal Antibodies
Toxicogenomics
Biomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cells
Blood Constituents
Cardiovascular Pharmacology
Central Nervous System
Chronobiology and the Implications for Safety Pharmacology
Cochlear Safety Tests
Drug Safety on Herbal Medical Products
Drug-Addiction and Drug-Dependency
Endocrine Pharmacology
Magnetic Resonance Imaging and Imaging in Pharmaceutical Safety Assessment
Metabolism Pharmacology
Ocular Safety Tests
Oncology Pharmacology
Peripheral Nervous System
Pulmonary Pharmacology
Renal System
Safe Chemicals / REACH
Safety Pharmacology in Biologics, Antibiotics and Monoclonics
Safety Pharmacology: Introduction and Guidelines
Sensory Systems
Skin Pharmacology
Stem Cells in Safety Pharmacology
Study design and statistics
Transgenic Animals
Zebrafish Model
Safety Toxicology
Genotoxicity
In silico Methods
In vitro toxicity testing
International Guidelines
OMICS Technologies
Reproductive Toxicology
Safety Toxicology: Introduction
Testing of Medical Devices
Testing of Monoclonal Antibodies
Toxicogenomics
H. Gerhard Vogel studied Pharmacy and Medicine at the Universities Erlangen and Tübingen (Germany). He received his Licensure as a Pharmacist in 1952 and as a Physician in 1956. His Doctorate in Medicine was gained in 1955. In 1963 he was designated a Fachpharmakologe DPhG. In 1967 he became Associate Professor in Pharmacology and Toxicology of the Department of Medicine, University of Marburg. In 1970 he was acknowledged as a Specialist for Pharmacology (Arzt für Pharmakologie). From 1972 he taught students of Medicine, Pharmacy and Biology as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Marburg and from 1979 as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Frankfurt. After working as a resident in medicine in a city hospital, he joined the Department of Pharmacology of Farbwerke Hoechst AG, Frankfurt as a pharmacologist and endocrinologist in 1958. In 1969 he was made Director of the Department of Pharmacology at Hoechst, in 1977 Head of Pharma Research Experimental Medicine, in 1980 Head of Pharma Research, Preclinical Evaluation and Development, and in 1989 Head of the Decision Board on Pharmaceutical Development.
His scientific work was devoted to elaboration of new pharmacological methods, pharmacology of plant extracts from various countries, pharmacology of steroid hormones, pharmacology of peptide hormones, pharmacology of cardiac glycosides, biomechanics and biochemistry of connective tissue, experimental gerontology, experimental dermatology, development procedures for pharmaceutical products. He published more than 160 papers, mainly on new pharmacological methods, endocrinology, especially peptide endocrinology, biomechanics and biochemistry of connective tissue, such as skin and bone, and on other topics. He was a member of many international and national scientific societies, such as The New York Academy of Science,
A landmark in the continuously changing world of drugs
Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
Of use for government institutions and committees working on official guidelines for drug evaluation worldwide
Date de parution : 03-2013
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 1243,85 €
Ajouter au panierDate de parution : 02-2013
Ouvrage de 1404 p.
19.2x26 cm
