Digestive System Diseases, 1st ed. 2019 Stem Cell Mechanisms and Therapies Stem Cell Biology and Regenerative Medicine Series

This book reviews recent knowledge of the role of stem cells in the gastrointestinal system. It covers extensive topics for each organ, including the pancreas, esophagus, liver, and colon, while also discussing the contributions of stem cells to therapeutic approaches toward gastrointestinal diseases, including inflammatory bowel diseases. Comprehensive and cutting-edge, Digestive System Diseases: Stem Cell Mechanisms and Therapies deepens a reader?s theoretical expertise in gastrointestinal stem cell biology. It furthers scientists? understanding of gastrointestinal stem cells and, most importantly, the development of novel therapeutic targets.

Graduate and postdoctoral students, medical doctors (including gastroenterologists and surgeons), and principal investigators in both academia and industry will benefit from this book. In particular, it is a valuable resource for professionals within the fields of gastrointestinal research, pharmaceutical science, molecular biology, regenerative medicine, and genetics.   

1. Introduction.- 2. Stem cells principles and biology.- 3. The truth behind esophagus: the stem cells significance.- 4. Pancreatic Diseases: The Role of Stem Cells.- 5. Stem cells therapy for liver diseases.- 6. The role of stem cells in colorectal cancer carcinogenesis and treatment.- 7. THE ROLE OF STEM CELLS IN THE TREATMENT OF ANAL FISTULAS.- 8. Stem cells in inflammatory bowel disease: From pathogenesis to clinical practice.- 9. Paneth Cells Physiology and Pathophysiology in Inflammatory Bowel Disease.

Maria Gazouli, PhD, Biologist, is Associate Professor of the Department of Biology at the National & Kapodistrian University of Athens (NKUA) School of Medicine. She performed her 1st PhD training at the Department of Biology, School of Science of NKUA in partnership with the Hellenic Pasteur Institute, her 2nd PhD training at the Department of Microbiology, School of Medicine of NKUA, and her postdoctoral work in the USA (1997-2000) in the Cell Biology and Pharmacology Department, Georgetown University Medical Center, Washington, DC. In 2007, she joined the NKUA Medical School as Lecturer of Biology, in 2012 she was promoted to Assistant Professor of Molecular Biology and, in late 2016, she was promoted to Associate Professor of Molecular Biology. Dr M. Gazouli’s work refers mainly to the molecular basis of diseases (mainly autoimmune diseases and cancer), to molecular detection of pathogens, and to the investigation of the pathogenesis of the diseases they cause to humans. She worked on stem cells implication in mucosal healing, and she is responsible for the e-learning program of the NKUA Stem Cells and Regenerative Medicine. Recently, Dr Gazouli was involved in the incorporation of nanotechnology into targeted cancer detection, imaging and drug delivery. She was honored with a Fulbright Scholarship for the Development of Nanotechnology-based Biosensor Arrays for the Detection of Circulating Colorectal Cancer Cells at University of Maryland, College Park, MD, USA. Dr Gazouli’s work is reflected in more than 230 publications that have received more than 8900 citations and an h-index of48 (Google scholar, 1/10/2018). She owns one granted international patent and three European patents. She has given more than 50 invited lectures at international and national conferences and universities and has trained several junior scientists. She has served as ad hoc reviewer for various high-impact scientific journals, and she is regularly invited to serve on review

Reviews current knowledge on the use of stem therapies in digestive system diseases

Leaders in the field from around the world contribute international perspective and expertise

In thorough but succinct detail, discusses the diseases which affect each part of the digestive system and the possible impact of stem cell therapy on them