Diabetes, Insulin and Alzheimer's Disease, 2010 Research and Perspectives in Alzheimer's Disease Series

This volume brings together experts from basic and clinical science to provide a broad survey of the role of insulin in the brain, and to discuss the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Each author has greatly furthered our understanding of the relationships among insulin, diabetes, and Alzheimers disease, moving us far beyond the belief that the brain is an insulin-insensitive organ. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.

Insulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease.- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies.- Insulin-Mediated Neuroplasticity in the Central Nervous System.- Stress Hormones and Neuroplasticity in the Diabetic Brain.- Diabetes and the Brain – An Epidemiologic Perspective.- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors.- The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective.- The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease.- Is Alzheimer’s a Disorder of Ageing and Why Don’t Mice get it? The Centrality of Insulin Signalling to Alzheimer’s Disease Pathology.- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD.- Diet, Abeta Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimer’s Disease.- Serum IGF-I, Life Style, and Risk of Alzheimer’s disease.

Includes supplementary material: sn.pub/extras